Molecularly confirmed high-grade endometrial stromal sarcoma (HGESS) cases in the literature
| Author | Year | Number of cases | Molecular method | FIGO stage at presentation | Presence of LGESS-like component histologically* |
|---|---|---|---|---|---|
| Ali et al18 | 2014 | 1 | FISH breakapart | IIIc | 0/1 |
| Gremel et al68 | 2014 | 3 | RT-PCR | NA | NA |
| Sciallis et al69 | 2014 | 4 | FISH breakapart | 1/4 stage IIIB 1/4 stage IIIC 2/4 stage IVB | NA |
| Stewart et al55 | 2014 | 4 | FISH breakapart | NA | 1/4 |
| Croce et al70 | 2013 | 6 | FISH breakapart and RT-PCR | 3/6 stage IB 1/6 stage IVB 2/6 NA | 1/6 at least † |
| Lee et al66‡ | 2012 | 13 | FISH breakapart and karyotyping | 10/12 stages II to III 2/12 stage I | 8/13 |
| Amant et al71 | 2011 | 1 | t(10;17) by karyotyping and M-FISH | IIIc | NA |
| Regauer et al72 | 2008 | 1 | t(10;17) by karyotyping and M-FISH | Recurrent abdominal mass | 1/1 |
| Micci et al73 | 2003 | 1 | t(10;17) by karyotyping and RxFISH | Metastatic to lung | NA |
| Leunen et al74 | 2003 | 1 | t(10;17) by karyotyping | III | NA |
*Some YWHAE-rearranged HGESSs contain an LGESS-like component that is fibrous or fibromyxoid.
†Three additional cases were described as ‘spindle’ with no details on the grade of these spindle areas.
‡Original paper that described YWHAE rearrangement in HGESS.
LGESS, low-grade endometrial stromal sarcoma; RT-PCR, reverse transcriptase-PCR; NA, not available.