Table 5

Main miRNAs deregulated in pancreatic cystic lesions

miRNA	Lesion	Regulation	References
miR-21	Malignant cyst fluid vs benign cyst fluid	Upregulated	30
	Invasive IPMN vs non-invasive IPMN vs normal controls	Upregulated	40
	IPMNs vs benign lesions	Upregulated	28
	IPMNs vs non-neoplastic pancreas	Upregulated	43
	IPMN vs PDAC	Downregulated	46
	IPMN vs PDAC	Downregulated	49
	Malignant lesions vs benign lesions vs normal controls	Upregulated	47
	Mucinous lesions vs non-mucinous cyst	Upregulated	29
miR-221	Malignant cyst fluid vs benign cyst fluid	Upregulated	30
	IPMNs vs non-neoplastic pancreas	Upregulated	43
	IPMN vs PDAC	Downregulated	49
	Mucinous lesions vs non-mucinous cyst	Upregulated	29
miR-155	Invasive IPMN vs non-invasive IPMN vs normal controls	Upregulated	40
	IPMNs vs non-neoplastic pancreas	Upregulated	43
	IPMN vs PDAC	Downregulated	49
	Malignant lesions vs benign lesions vs normal controls	Upregulated	47
miR-210	IPMNs vs non-neoplastic pancreas	Upregulated	43
miR-130a	HR-IPMN vs LR-IPMN	Downregulated	51

HR, high risk; IPMN, intraductal papillary mucinous neoplasia; LR, low risk; PDAC, pancreatic ductal adenocarcinoma.