Primary tumour KRAS/NRAS/BRAF/PIK3CA mutation status of DPYD gene variant carriers
| DPYD gene variants | |||
|---|---|---|---|
| c.496A>G (n=15) | c.2846A>T (n=6) | c.1679T>G (n=3) | |
| KRAS wild type (n=65) | 15 (23.1%) | 4 (6.1%) | 3 (4.6%) |
| KRAS mutation (n=51) | 0 (0%) | 2 (3.9%) | 0 (0%) |
| p=0.0001 | n.s. | n.s. | |
| NRAS wild type (n=110) | 15 (13.6%) | 6 (5.4%) | 3 (2.7%) |
| NRAS mutation (n=6) | 0 (0%) | 0 (0%) | 0 (0%) |
| n.s. | n.s. | n.s. | |
| BRAF wild type (n=101) | 13 (12.9%) | 3 (3%) | 3 (3%) |
| BRAF mutation (n=15) | 2 (13.3%) | 3 (20%) | 0 (0%) |
| n.s. | p=0.028 | n.s. | |
| PIK3CA wild type (n=108) | 14 (13%) | 6 (5.6%) | 3 (2.8%) |
| PIK3CA mutation (n=8) | 1 (12.5%) | 0 (0%) | 0 (0%) |
| n.s. | n.s. | n.s. | |
n.s., not significant.