Table 2

Primary tumour KRAS/NRAS/BRAF/PIK3CA mutation status of DPYD gene variant carriers

 DPYD gene variants
c.496A>G (n=15)c.2846A>T (n=6)c.1679T>G (n=3)
KRAS wild type (n=65)15 (23.1%)4 (6.1%)3 (4.6%)
KRAS mutation (n=51)0 (0%)2 (3.9%)0 (0%)
p=0.0001n.s.n.s.
NRAS wild type (n=110)15 (13.6%)6 (5.4%)3 (2.7%)
NRAS mutation (n=6)0 (0%)0 (0%)0 (0%)
n.s.n.s.n.s.
BRAF wild type (n=101)13 (12.9%)3 (3%)3 (3%)
BRAF mutation (n=15)2 (13.3%)3 (20%)0 (0%)
n.s.p=0.028n.s.
PIK3CA wild type (n=108)14 (13%)6 (5.6%)3 (2.8%)
PIK3CA mutation (n=8)1 (12.5%)0 (0%)0 (0%)
n.s.n.s.n.s.
  • n.s., not significant.