Gene | Predicted to be actionable | Substitution/indel | Amp | Deletion | Truncation | Fusion/rearrangement | Number of samples | Percentage of samples (%) |
---|---|---|---|---|---|---|---|---|
TP53 | No | 46 | 0 | 3 | 35 | 0 | 84 | 86 |
RB1 | No | 2 | 0 | 12 | 39 | 0 | 53 | 54 |
MLL2 | No | 1 | 0 | 0 | 16 | 0 | 17 | 17 |
RICTOR | Yes | 0 | 10 | 0 | 0 | 0 | 10 | 10 |
MYCL1 | No | 0 | 8 | 0 | 0 | 0 | 8 | 8 |
FGF10 | No | 0 | 8 | 0 | 0 | 0 | 8 | 8 |
LRP1B | No | 0 | 0 | 0 | 7 | 0 | 7 | 7 |
KIT | Yes | 3 | 2 | 0 | 2 | 0 | 7 | 7 |
PIK3CA | Yes | 3 | 3 | 0 | 0 | 0 | 6 | 6 |
PTEN | Yes | 1 | 0 | 2 | 2 | 0 | 5 | 5 |
MYST3 | No | 0 | 5 | 0 | 0 | 0 | 5 | 5 |
KRAS | Yes | 4 | 1 | 0 | 0 | 0 | 5 | 5 |
EGFR | Yes | 5 | 0 | 0 | 0 | 0 | 5 | 5 |
ZNF703 | No | 0 | 4 | 0 | 0 | 0 | 4 | 4 |
SPEN | No | 0 | 0 | 0 | 4 | 0 | 4 | 4 |
SOX2 | No | 0 | 4 | 0 | 0 | 0 | 4 | 4 |
MYC | No | 0 | 4 | 0 | 0 | 0 | 4 | 4 |
MCL1 | Yes | 0 | 4 | 0 | 0 | 0 | 4 | 4 |
FGFR1 | Yes | 0 | 4 | 0 | 0 | 0 | 4 | 4 |
BRCA2 | Yes | 0 | 0 | 0 | 4 | 0 | 4 | 4 |
TSC1 | Yes | 0 | 0 | 1 | 2 | 0 | 3 | 3 |
NOTCH3 | No | 0 | 0 | 0 | 3 | 0 | 3 | 3 |
NKX2-1 | No | 0 | 3 | 0 | 0 | 0 | 3 | 3 |
NF1 | Yes | 0 | 0 | 1 | 2 | 0 | 3 | 3 |
KDM6A | No | 0 | 0 | 0 | 3 | 0 | 3 | 3 |
EPHA3 | Yes | 0 | 3 | 0 | 0 | 0 | 3 | 3 |
CSF1R | No | 3 | 0 | 0 | 0 | 0 | 3 | 3 |
CREBBP | No | 2 | 0 | 0 | 1 | 0 | 3 | 3 |
CCND1 | Yes | 0 | 3 | 0 | 0 | 0 | 3 | 3 |
SCLC, Small cell lung cancer.