Bone marrow morphology, p-STAT5 IHC and molecular data
| Case | Cellularity (%) | Megakaryocyte morphology | Marrow fibrosis | p-STAT5 IHC | JAK2 V617F | CALR exon 9 mutation |
|---|---|---|---|---|---|---|
| 1 | 40 | Small, hypolobated | MF-0 | Pos | Neg | NS |
| 2 | 90 | Small, hypolobated | MF-2 | Pos | Neg | Neg |
| 3 | 100 | Small, hypolobated | NE | Pos | Neg | Neg |
| 4 | 60 | Varying size, hypolobated | MF-1 | Pos | Neg | Neg |
| 5 | 90 | Small, hypolobated | NE | Pos | Neg | Neg |
| 6 | 100 | Small, hypolobated | MF-0 | Neg | Neg | NS |
| 7* | NE | NE | NE | |||
| 7† | 90 | Large with complex lobations | MF-2 | Pos | Pos | NS |
| 8 | 100 | Small, hypolobated | NE | Pos | Neg | Neg |
| 9 | >90 | Small, hypolobated | NE | Pos | Neg | Neg |
| 10 | >90 | Small, hypolobated | NE | Pos | Neg | Neg |
| 11 | >90 | Small, hypolobated | NE | Pos | Neg | NS |
| 12 | 90 | Small, hypolobated; MKBL present | MF-2 | Neg | Neg | Neg |
*At diagnosis.
†27 months after initial diagnosis.
CALR, calreticulin; IHC, immunohistochemistry; MF-0, scattered linear reticulin with no intersections corresponding to normal bone marrow; MF-1, loose network of reticulin with many intersections, especially in perivascular areas; MKBL, megakaryoblasts; NE, not evaluated; Neg, negative; NS, not successful; Pos, positive; p-STAT5, phospho-STAT5.