The correlation of microRNA-451 expression level with different clinical and pathological parameters in patients with colorectal carcinoma
| Parameters | Total no. | High expression | Low expression | Normal expression | p Value |
|---|---|---|---|---|---|
| Age | |||||
| ≤60 | 14 (20.0%) | 2 (14.3%) | 11 (78.6%) | 1 (7.1%) | 0.507 |
| >60 | 56 (80.0%) | 3 (5.4%) | 48 (85.7%) | 5 (8.9%) | |
| Gender | |||||
| Male | 35 (50.0%) | 1 (2.9%) | 32 (91.4%) | 2 (5.7%) | 0.236 |
| Female | 35 (50.0%) | 4 (11.4%) | 27 (77.1%) | 4 (11.4%) | |
| Size | |||||
| ≤40 mm | 39 (55.7%) | 2 (5.1%) | 33 (84.6%) | 4 (10.3%) | 0.673 |
| >40 mm | 31 (44.3%) | 3 (9.7%) | 26 (83.9%) | 2 (6.5%) | |
| Location | |||||
| Colon | 54 (77.1%) | 5 (9.3%) | 45 (83.3%) | 4 (7.4%) | 0.391 |
| Rectum | 16 (22.9%) | 0 (0.0%) | 14 (87.5%) | 2 (12.5%) | |
| Grade | |||||
| I | 9 (12.9%) | 0 (0.0%) | 9 (100.0%) | 0 (0.0%) | 0.340 |
| II | 52 (74.3%) | 5 (9.6%) | 41 (78.8%) | 6 (11.5%) | |
| III | 9 (12.9%) | 0 (0.0%) | 9 (100.0%) | 0 (0.0%) | |
| Stage | |||||
| I/II | 41 (58.6%) | 4 (9.8%) | 35 (85.4%) | 2 (4.9%) | 0.282 |
| III/IV | 29 (41.4%) | 1 (3.4%) | 24 (82.8%) | 4 (13.8%) | |
| Associated adenoma | |||||
| Yes | 35 (50.0%) | 0 (0.0%) | 32 (91.4%) | 3 (8.6%) | 0.025 |
| No | 35 (50.0%) | 5 (14.3%) | 27 (77.1%) | 3 (8.6%) | |
| Lymphovascular permeation | |||||
| Yes | 15 (21.4%) | 0 (0.0%) | 14 (93.3%) | 1 (6.7%) | 0.443 |
| No | 55 (78.6%) | 5 (9.1%) | 45 (81.8%) | 5 (9.1%) | |
| Perineural infiltration | |||||
| Yes | 6 (8.6%) | 1 (16.7%) | 4 (66.7%) | 1 (16.7%) | 0.455 |
| No | 64 (91.4%) | 4 (6.3%) | 55 (85.9%) | 5 (7.8%) | |
| Microsatellite instability status | |||||
| Yes | 12 (17.1%) | 2 (16.7%) | 9 (75.0%) | 1 (8.3%) | 0.370 |
| No | 58 (82.9%) | 3 (5.2%) | 50 (86.2%) | 5 (8.6%) | |
| Hereditary non-polyposis colorectal cancer | |||||
| Presence | 6 (8.6%) | 0 (0.0%) | 6 (100.0%) | 0 (0.0%) | 0.542 |
| Not detected | 64 (91.4%) | 5 (7.8%) | 53 (82.8% | 6 (9.4%) | |
| Cancer recurrence | |||||
| Yes | 20 (28.6%) | 0 (0.0%) | 16 (80.0%) | 4 (20.0%) | 0.028 |
| No | 50 (71.4%) | 5 (10.0%) | 43 (86.0%) | 2 (4.0%) | |
Bold is p value<0.05.