Characteristics of study cohort
| Phyllodes tumour | ||||||
|---|---|---|---|---|---|---|
| Parameters | All cases | Fibroadenoma | Benign | Borderline | Malignant | p Value |
| Median age (range), years old | 39 (15–79) | 32 (19–54) | 40 (16–67) | 44 (15–79) | 51 (20–68) | <0.001*; 0.023† |
| Median tumour size (range), mm | 30 (6–250) | 25 (6–55) | 35 (13–180) | 50 (20–250) | 70 (20–220) | <0.001*; 0.002† |
| Ethnicity, count (%) | 0.704*; 0.173† | |||||
| Chinese | 139 (59.9) | 60 (60) | 44 (57.1) | 29 (70.7) | 6 (42.9) | |
| Malay | 29 (12.5) | 12 (12) | 11 (14.3) | 2 (4.9) | 4 (28.6) | |
| Indian | 16 (6.9) | 9 (9) | 6 (7.8) | 1 (2.4) | 0 (0) | |
| Others | 48 (20.7) | 19 (19) | 16 (20.8) | 9 (22.0) | 4 (28.6) | |
| MED12 variant, count (%) | 0.246*; 0.582† | |||||
| Wild type | 78 (36.8) | 36 (41.9) | 23 (31.5) | 13 (32.5) | 6 (46.2) | |
| Mutant | 134 (63.2) | 50 (58.1) | 50 (68.5) | 27 (67.5) | 7 (53.8) | |
| Missense | 103 | 40 | 38 | 22 | 3 | |
| Indels | 26 | 8 | 9 | 5 | 4 | |
| Splice site | 5 | 2 | 3 | 0 | 0 | |
*Fibroadenomas versus phyllodes tumours.
†Benign versus borderline versus malignant phyllodes tumours.