Table 1

Summary of the cohort studied

JAK2V617F and CALR mutation statusTotal
SubtypeJAK2V617F+CALRMutJAK2V617F−/CALRWTUnknown
Controls1515
PV2020
ET26963172
MF*181451653
Total64232647160
  • JAK2V617F and CALR lesions did not coexist (ie, JAK2V617F+ and CALRMut were mutually exclusive). All CALR mutations represent frameshift lesions in exon 9 of CALR.

  • *Includes both primary MF and ET/PV cases having undergone fibrotic transformation.

  • CALR, calreticulin; ET, essential thrombocythaemia; JAK2, Janus activated kinase 2; MF, myelofibrosis; Mut, mutated; PV, polycythaemia vera; WT, wild type.