Relative risk of death from breast cancer according to MVD, pMVD and VPI by tumour subtype
| Unadjusted HR | 95% CI | Adjusted* HR | 95% CI | Adjusted† HR | 95% CI | |
|---|---|---|---|---|---|---|
| MVD, microvessels/mm2 | ||||||
| BP, per 10 vessel increase | 1.06 | 0.96 to 1.16 | 1.05 | 0.95 to 1.15 | 1.04 | 0.94 to 1.14 |
| HER2 type, per 10 vessel increase | 1.07 | 1.03 to 1.12 | 1.07 | 1.02 to 1.12 | 1.07 | 1.02 to 1.12 |
| 5NP per 10 vessel increase | 1.10 | 1.03 to 1.18 | 1.10 | 1.02 to 1.18 | 1.13 | 1.03 to 1.23 |
| pMVD, microvessels/mm2 | ||||||
| BP, per single-vessel increase | 1.08 | 1.00 to 1.16 | 1.09 | 1.00 to 1.18 | 1.06 | 0.97 to 1.16 |
| HER2 type, per single-vessel increase | 1.03 | 1.00 to 1.07 | 1.03 | 1.00 to 1.07 | 1.05 | 1.01 to 1.08 |
| 5NP, per single-vessel increase | 0.94 | 0.83 to 1.06 | 0.96 | 0.85 to 1.10 | 0.96 | 0.79 to 1.16 |
| VPI, percentage points | ||||||
| BP, per 1 percentage point increase | 1.08 | 0.99 to 1.19 | 1.08 | 0.98 to 1.19 | 1.06 | 0.95 to 1.18 |
| HER2 type, per 1 percentage point increase | 0.99 | 0.92 to 1.07 | 0.99 | 0.91 to 1.07 | 1.05 | 0.97 to 1.15 |
| 5NP, per 1 percentage point increase | 0.87 | 0.75 to 1.02 | 0.89 | 0.74 to 1.06 | 0.81 | 0.63 to 1.04 |
*Adjusted for age.
†Adjusted for age, grade, stage.
5NP, five negative phenotype; BP, basal phenotype; HER2, human epidermal growth factor receptor 2; MVD, microvessel density; pMVD, proliferating microvessel density; VPI, vascular proliferation index.