Table 4

Immunohistochemical markers in the differential diagnosis of endometrial mesenchymal tumours

Endometrial mesenchymal tumours
LGESS+++wt + JAZF1–SUZ12 fusion
HGESS+ wt YWHAE–NUTM2A/B fusion, cyclin D1, c-Kit,
Ki-67 high
LM+++wt ++Actin
LMS+ /+ /+M>wt+ ++Ki-67 high
  • p53 M corresponds to intense and diffuse positivity in ≥60% of cells or complete negativity; p53 wt is the presence of rare cells weakly positive or positivity in <60% of cells.

  • desm, desmin; h-cald, h-caldesmon; HGESS, high-grade endometrial stromal sarcoma; LGESS, low-grade endometrial stromal sarcoma; LM, leiomyoma; LMS, leiomyosarcoma; M, mutant pattern; wt, wild-type pattern.