Table 1

Established tissue-based molecular tests (adapted from Flynn et al 25)

Lymphoma translocation detectionKRAS/NRAS mutation testingMSI testing
Clonality testingc-KIT and PDGFRA mutation analysisMMR protein expression
Sarcoma translocation detectionBRAF mutation testing
EGFR mutation testing
ALK protein expression
EML4-ALK translocation detection
CNS tumours—multiple
ER, PR and HER2 protein expression
HER2 amplification
  • CNS, central nervous system; MMR, mismatch repair; MSI, microsatellite instability.