Table 2

Panels of the mutations detected the different Idylla cartridges

Idylla BRAF Mutation Test (CE-IVD) Idylla EGFR Mutation Test (CE-IVD)
BRAF V600E (c.1799T>A; c.1799_1800delinsAA)
BRAF V600D (c.1799_1800delinsAT*; c.1799_1800delinsAC)
BRAF V600K (c.1798 _ 1799delinsA A)
BRAF V600R (c.1798 _ 1799delinsAG)
BRAF V600M (c.1798G>A)*		Exon 18
EGFR G719A (c.2156G>C)
EGFR G719C (c.2155G>T;c.2154_2155delinsTT)
EGFR G719S (c.2155G>A)
Exon 19
Del9
(c.2238_2248delinsGC; c.2239_2248delinsC; c.2240_ 2248del; c.2239 _2247del)
Del12
(c.2239_2251delinsC;c.2240_2251del)
Del15
(c.2235_2249del; c.2236_2250del; c.2239_2253del; c.2240_2254del; c.2238_2252del; c.2237_2251del; c.2235_2252delinsAAT; c.2237_2252delinsT; c.2234_2248del; c.2236_2253delinsCTA; c.2237_2253delinsTA; c.2237_2253delinsTC; c.2235_2251delinsAG; c.2236_2253delinsCAA; c.2230_2249delinsGTCAA)
Del18
(c.2240_ 2257del; c.2237_2255delinsT;
c.2239_2256del; c.2236_2253del;
c.2239_2258delinsCA; c.2237_2254del;
c.2238_2255del; c.2237_2257delinsTCT;
c.2236_2255delinsAT; c.2236_2256delinsATC;
c.2237_2256delinsTT; c.2237_2256delinsTC;
c.2235_2255delinsGGT)
Del21
(c.2238_2258del; c.2236_2256del)
Del24 (c.2253_2276del)
Exon 20
EGFR T790M (c.2369C>T)
EGFR S768I (c.2303G>T) insG (c.2310_2311insGGT) insASV9 (c.2308_2309insGCCAGCGTG) insASV11 (c.2308_2311delinsCCAGCGTGGAT) insSVD (c.2311_2312insGCGTGGACA) insH (c.2319_2320insCAC)
Exon 21
EGFR L858R (c.2573T>G;c.2573_2574delinsGT;
c.2573_2574delinsGA)
EGFR L861Q (c.2582T>A)
Idylla NRAS Mutation Test (CE-IVD)
NRAS G12C (c.34 G>T)
NRAS G12S (c.34 G>A)
NRAS G12D (c.35G>A)
NRAS G12A (c.35G>C)
NRAS G12V (c.35G>T)
NRAS G13D (c.38G>A)
NRAS G13V (c.3 8G>T)
NRAS G13R (c.37G>C)
NRAS A59T (c.175G>A)
NRAS Q61K (c.181C>A)
NRAS Q61L (c.182A>T)
NRAS Q61R (c.182A>G)
NRAS Q61H (c.183A>C; c.183A>T)
NRAS K117N (c.351G>C; c.351G>T)
NRAS A146T (c.436G>A)
NRAS A146V (c.437C>T)
Idylla NRAS-BRAF Mutation Test (CE-IVD)
Same panels as Idylla BRAF Mutation Test (CE-IVD) and Idylla NRAS Mutation Test (CE-IVD) except BRAF mutations marked with an *
Idylla NRAS-BRAF-EGFR S492R Mutation Assay (RUO)
Same panels as Idylla BRAF Mutation Test (CE-IVD) and Idylla NRAS Mutation Test (CE-IVD) except BRAF mutations marked with an *. Detects also EGFR S492R (c.1476C>A; c.1474A>C) mutations.
Idylla KRAS Mutation Test (CE-IVD)
KRAS G12C (c.34G>T)
KRAS G12R (c.34G>C)
KRAS G12S (c.34G>A)
KRAS G12A (c.35G>C)
KRAS G12D (c.35G>A)
KRAS G12V (c.35G>T)
KRAS G13D (c.38G>A)
KRAS A59E (c.176C>A)
KRAS A59G (c.176C>G)
KRAS A59T (c.175G>A)
KRAS Q61K (c.181C>A; c.180_ 181delinsAA)
KRAS Q61L (c.182 A>T)
KRAS Q61R (c.182A>G)
KRAS Q61H (c.183A>C; c.183A>T)
KRAS K117N (c.351A>C; c.351A>T)
KRAS A146P (c.436G>C)
KRAS A146T (c.436G>A)
KRAS A146V (c.437C>T)

  • CE-IVD, European Community for in vitro diagnostic use.