Table 3

Correlation with clinic-pathological features and biomarkers in TNBC and non-TNBC

		TNBC				Non-TNBC
		CD147				CD147
		Absent	Low	High	P values	Absent	Low	High	P values
Grade	1	6	0	0	0.002	140	13	6	0.869
	2	29	1	0		392	30	7
	3	93	29	10		362	32	11
Apocrine	Absent	113	26	9	0.808	825	65	22	0.187
	Present	15	3	1		66	10	2
FF	Absent	92	22	7	0.997	664	53	17	0.634
	Present	36	8	3		212	21	7
Necrosis	Absent	82	16	3	0.020	723	51	20	0.189
	Present	44	14	7		141	18	4
LVI	Absent	95	21	6	0.146	610	51	18	0.420
	Present	27	9	4		242	20	4
EIC	Absent	108	28	10	0.070	701	61	19	0.813
	Present	20	2	0		183	13	5
pT	1	44	7	3	0.988	359	34	11	0.447
	2	65	21	6		469	35	12
	3	13	1	1		41	3	1
	4	5	1	0		13	2	0
pN	0	62	20	4	0.356	433	30	12	0.585
	1	35	6	5		255	21	5
	2	16	3	0		109	11	5
	3	11	1	1		77	7	1
TIL	≤20%	73	15	4	0.718	551	47	13	0.317
	>20%	31	3	4		124	10	6
Subtype	LumA	–	–	–	0.008	487	32	12	0.070
	LumB	–	–	–		303	38	10
	HER2-OE	–	–	–		106	6	2
	BLBC	52	19	8		–	–	–
	5 NP	76	11	2		–	–	–
Age	Mean	56.9	55.7	48.8	0.162	54.2	52.0	60.2	0.042
	SD	13.7	11.6	9.7		12.6	12.7	14.1
	Range	28–94	42–89	33–67		22–97	30–89	43–85
Tumour size	Mean	2.95	2.96	3.16	0.624	2.67	2.58	2.54	0.761
	SD	1.58	1.08	1.59		1.46	1.39	1.50
	Range	1.0–8.0	1.0–6.0	1.0–7.0		0.1–13.0	1.0–7.0	1.0–8.0
Biomarker
ER	Neg	–	–	–		158	15	5	0.554
	Pos					738	61	19
PR	Neg	–	–	–		203	18	4	0.685
	Pos					689	58	20
HER2	Neg	–	–	–		693	59	21	0.500
	Pos					203	17	3
Ki67	Lo	83	12	5	0.033	699	43	15	< 0.001
	Hi	45	18	5		191	32	9
EGFR	Neg	114	22	8	0.046	855	69	20	0.021
	Pos	13	8	2		34	7	2
P63	Neg	119	27	9	0.363	859	72	22	0.137
	Pos	7	3	1		30	4	2
C-kit	Neg	91	15	6	0.062	785	59	19	0.005
	Pos	36	15	4		100	17	5
CK5/6	Neg	81	13	2	0.001	822	65	19	0.002
	Pos	46	17	8		66	11	5
CK14	Neg	106	17	7	0.010	865	68	24	0.072
	Pos	21	13	3		24	8	0
α–β crystalline	Neg	20	3	1	0.209	369	37	12	0.598
	Pos	16	5	2		27	4	1
NGFR	Neg	31	4	2	0.066	364	37	9	0.049
	Pos	5	4	1		37	4	4
E-cadherin	Neg	12	6	0	0.701	66	3	2	0.515
	Pos	106	22	8		778	70	22
Vimentin	Neg	86	10	4	0.001	760	61	13	< 0.001
	Pos	31	18	4		75	10	11
p-cadherin	Neg	56	9	0	0.004	691	55	18	0.068
	Pos	60	19	8		140	18	6
CD44	Neg	26	2	1	0.016	276	24	9	0.384
	Pos	10	6	2		123	17	4
SOX2	Neg	23	6	3	0.191	327	32	10	0.490
	Pos	13	2	0		73	9	3
ALDH	Neg	33	6	3	0.495	378	37	13	0.991
	Pos	2	2	0		23	4	0
AR	Neg	91	27	6	0.078	412	34	8	0.167
	Pos	27	1	2		429	39	16

ALDH, aldehyde dehydrogenase; AR, androgen receptor; BLBC, basal-like breast cancer; EGFR, epidermal growth factor receptor; EIC, extensive in situ component; ER, oestrogen receptor; FF, fibrotic focus; HER2, human epidermal growth factor receptor 2; LVI, lymphovascular invasion; NGFR, nerve growth factor receptor; PR, progesterone receptor; TIL, tumour-infiltrating lymphocyte; TNBC, triple-negative breast cancer.