Table 2

Outcome of different grading strategies of each individual pathologist

P1P2P3Reference Standard*
n
nnn
A. H&E scoring
 No dysplasia263444
 CIN1311117
 CIN216820
 CIN3204012
 SCC222222
B. Ki-67 and p16ink4a immunoscore
 Immunoscore 025200
 Immunoscore 1211037
 Immunoscore 2496
 Immunoscore 3755
 Immunoscore 4435
 Immunoscore 59710
 Immunoscore 6456152
C. Combined H&E and non-objectified IHC score
 No dysplasia28354135
 CIN124121919
 CIN22181817
 CIN320381522
 CIN322222222
  • *The Reference Standard is defined as the majority diagnosis of the combined H&E and non-objectified IHC score, based on agreement on CIN grade in two out of three pathologists (see also the Methods section).

  • CIN, cervical intraepithelial neoplasia; IHC, immunohistochemistry; P, pathologist; SCC, squamous cell carcinoma.