Genes fused | |
I. Tumours with >90% fusions | |
Salivary gland mammary analogue secretory carcinoma | ETV6-NTRK3 |
Breast secretory carcinoma | ETV6-NTRK3 |
Infantile fibrosarcoma | LMNA-NTRK1 |
Congenital mesoblastic nephroma | ETV6-NTRK3 |
Lipofibromatosis-like neural tumour | TPR-NTRK1 and TPM3-NTRK-1 |
II. Tumours with 5%–25% fusions | |
Thyroid papillary carcinoma | ETV6-NTRK3, TGF-NTRK1 and TPM3-NTRK1 |
Gastrointestinal stromal tumour | ETV6-NTRK3 |
Spitzoid melanoma | TP53-NTRK1 and LMNA-NTRK1 |
III. Tumours with 1%–5% fusions | |
High-grade gliomas/glioblastoma multiforme | P53-NTRK1, NFASC-NTRK1, BCAN-NTRK1, AGBL4-NTRK2 and BTBD1-NTRK3 |
Low-grade glioma/pilocytic astrocytoma | AFAP-NTRK2, NACC2-NTRK2 and QK1-NTRK2 |
Head and neck squamous carcinoma | PAN3-NTRK2 |
Lung non-small cell carcinoma | SQSTM1-NTRK1 |
Lung adenocarcinoma | CD74-NTRK1, MPRIP-NTRK1 and TRIM24-NTRK2 |
Lung large cell neuroendocrine carcinoma | RFWD2-NTRK1 |
Breast ductal carcinoma | ETV6-NTRK3 |
Acute myeloid leukaemia | ETV6-NTRK3 |
Acute lymphoblastic leukaemia | ETV6-NTRK3 |
Multiple myeloma | UBE2R2-NTRK3 and HNRNPA2B1-NTRK3 |
Cholangiocarcinoma | RABGAP1L-NTRK1 |
Colorectal cancer | TP53-NTRK1 |
Uterine sarcoma | TPM3-NTRK1, LMNA-NTRK1, RBPMS-NTRK-3 and TPR-NTRK-1 |
NTRK, neurotrophic tropomyosin/tyrosine receptor kinase.