Clinicopathological features of HPVA vs NHPVA
| HPVA | NHPVA | P value | |
| 71 (82%) | 16 (18%) | ||
| Age at diagnosis (years) (n=87) | <0.001 | ||
| Median | 40 | 58 | |
| Range | 22–80 | 17–69 | |
| Horizontal extent (mm) (n=67) | 0.013 | ||
| Median | 9.0 | 21.0 | |
| Range | 2.0–50.0 | 2.0–45.0 | |
| Depth of invasion (mm) (n=66) | 0.003 | ||
| Median | 4.5 | 11.0 | |
| Range | 1.0–25.0 | 4.0–30.0 | |
| Lymphovascular invasion (n=71) | <0.001 | ||
| Present | 11 (18%) | 8 (73%) | |
| Absent | 49 (82%) | 3 (27%) | |
| Lymph node involvement (n=42) | 0.097 | ||
| Present | 2 (6%) | 2 (25%) | |
| Absent | 32 (94%) | 6 (75%) | |
| Stage (n=83) | <0.001 | ||
| I | 60 (89%) | 4 (25%) | |
| II | 6 (9%) | 2 (13%) | |
| III | 1 (2%) | 3 (18%) | |
| IV | 0 | 7 (44%) | |
| Pattern of invasion (n=87) | <0.001 | ||
| A | 21 (30%) | 0 | |
| B | 27 (38%) | 1 (6%) | |
| C | 23 (32%) | 15 (94%) | |
| Primary treatment modality (n=87) | 0.142 | ||
| Surgical resection | 60 (84%) | 11 (69%) | |
| Chemoradiation | 11 (16%) | 5 (31%) | |
| Disease progression/recurrence (n=78) | 0.005 | ||
| Present | 9 (15%) | 8 (50%) | |
| Absent | 53 (85%) | 8 (50%) | |
| Death of disease (n=78) | <0.001 | ||
| Yes | 2 (3%) | 7 (44%) | |
| No | 60 (97%) | 9 (66%) |
HPVA, human papillomavirus–associated adenocarcinoma; NHPVA, non-human papillomavirus–associated adenocarcinoma.