Table 1

NTRK gene fusions identified in adult and paediatric cancers by relative frequency of NTRK gene fusions

Fusion partner
Tumour NTRK1 NTRK2 NTRK3
Adult cancers
High frequency (>80%)
 Mammary analogue secretory carcinomas   ETV6 11
 Secretory breast carcinoma   ETV6 12
Intermediate frequency (5%–25%)
 Papillary thyroid cancer TFG, 13 SSBP2, 9 SQSTM1, 9 TPR, 7 PPL 7   ETV6, 9 43 RBPMS 9
Low frequency (<5%)
 Appendiceal cancer LMNA 18   
 Glioma/glioblastoma ARHGEF2, 19 BCAN, 20 21 CHTOP, 19 NFASC 20 BCR, 18 AFAP1, 9 SQSTM1 9 AFAP1, 18 ZNF710, 18 EML4 18
 Astrocytoma  QK1, 7 NACC2 7  
 Gastrointestinal stromal tumour   ETV6 15
 Head and neck cancer  PAN3 9 LYN 9
 Lung cancer CD74, 7 GRPAP1, 23 IRF2BP2, 18 MPRIP, 7 P2RY8, 18 SQSTM1, 24 TPM3 18 TRIM24 9  
 Sarcoma TPM3, 9 LMNA 18   TPM4 10
 Breast cancer CGN, 25 GATAD2B, 25 LMNA, 25 MDM4, 25 PEAR1, 25 TPM3, 10 25   ETV6 25
 Acute lymphoblastic leukaemia, acute myeloid leukaemia, histiocytosis, multiple myeloma, dendritic cell neoplasms   ETV6 26
 Uterine sarcoma LMNA, 27 TPM3, 27 TPR 27   RBPMS 27
 Cholangiocarcinoma LMNA, 10 RABGAP1L 28   
 Pancreatic cancer CTRC 10   
 Melanoma DDR2, 29 GON4L, 29 TRIM63 29 TRAF2 29 ETV6 9
 Colorectal cancer LMNA, 10 TPM3, 10 SCYL3 30   ETV6 18
Paediatric cancers
High frequency (>80%)
 Secretory breast carcinoma   ETV6 12
 Infantile fibrosarcoma and other mesenchymal tumours SQSTM1, 31 TPM3, 41 LMNA 41   EML4, 32 41 ETV6 34 63
 Cellular and mixed congenital mesoblastic nephroma TPR, 40 LMNA 40  EML4,32 40 ETV633 40
Intermediate frequency (5%–25%)
 Papillary thyroid cancer TPR, 35 IRF2BP2, 10 TPM3 14   ETV6 35
 Spitz tumours TP53, 16 LMNA 16   ETV6, 17 MYH9, 17 MYO5A 17
 Paediatric high-grade gliomas TPM3 36 AGBL4, 36 VCL 36 ETV6, 36 BTB1 36
Low frequency (<5%)
 Ganglioglioma  TLE 38  
 Astrocytoma  NACC2, 37 QK1 37