Summarised information on role of circPVT1 in malignancy of different organs
| Circular RNA | Disease (cancer) | Molecular alteration | Functional role | Target miRNA | Downstream oncogenic effector | Clinical importance | Reference |
| Circular PVT1 | Gastric cancer | Genomic amplification Overexpression | Proliferation (↑) | miR-125b | E2F2 | Prognostic | Chen et al 14 |
| HNSCC | Overexpression | Proliferation (↑) Migration (−) | miR-497-5p | AURKA, MKI67 and BUB1 | Prognostic Therapeutic | Verduci et al 15 | |
| Acute lymphoblastic leukaemia | Overexpression | Proliferation (↑) Apoptosis (↓) | miR-125, miR-let7 | c-Myc, Bcl-2 | Therapeutic | Hu et al 28 | |
| Osteosarcoma | Overexpression | Proliferation (↑) Chemoresistance (↑) | Unknown | ABCB1 | Diagnostic Prognostic Therapeutic | Kun-Peng et al 53 | |
| NSCLC | Overexpression | Proliferation (↑) Apoptosis (↓) | miR-497 | Bcl-2 | Prognostic Therapeutic | Qin et al 54 |
↑, positive impact; ↓, negative impact; −, no effect.
HNSCC, head and neck squamous cell carcinoma; NSCLC, non-small cell lung carcinoma.