Table 1

Stages and phases reported for various tau pathologies and amyloid-beta deposition

Amyloid-beta (AD)38 Frontal, parietal, temporal or occipital neocortex.Phase 1
Entorhinal region, CA1 and in the insular cortex.Phase 2
Basal ganglia, basal forebrain nuclei, thalamus, hypothalamus, white matter.Phase 3
Inferior olivary nucleus, the reticular formation of the medulla oblongata, substantia nigra, CA4, central grey of the midbrain, colliculi superiores and inferiores, red nucleus.Phase 4
Different nuclei of the pons, cerebellum.Phase 5
Tau (AD)45 46 162 Locus coeruleus, magnocellular nuclei of the basal forebrain.Stage a–c
Transentorhinal region.Stage I
Entorhinal cortex.Stage II
Fusiform and lingual gyri, amygdala, anterior thalamus.Stage III
Superior temporal gyrus.Stage IV
Frontal, superolateral and occipital (peristriate) regions, striatum.Stage V
Secondary and primary neocortical regions and striate area in the occipital lobe, substantia nigra.Stage VI
Tau (AGD)107 150 Ambient gyrus.Stage 1
Anterior and posterior medial temporal lobe, temporal pole, subiculum, entorhinal cortex.Stage 2
Septum, insular cortex and anterior cingulate gyrus.Stage 3
Neocortex and brainstem.Stage 4
Tau (Pick)149 Frontotemporal limbic/paralimbic and neocortical regions.Phase 1
Basal ganglia, locus coeruleus and raphe nuclei.Phase 2
Primary motor cortex and precerebellar nuclei.Phase 3
Visual cortex.Phase 4
Tau (astro-PSP)30 Striatum.Stage 1
Frontal-parietal to temporal, to occipital.Stage 2
Amygdala.Stage 3
Brainstem.Stage 4
Tau (astro-CBD)30 Frontal-parietal.Stage 1
Temporal to occipital.Stage 2
Striatum and/or amygdala.Stage 3
Brainstem.Stage 4
Tau (GM ARTAG)30 Striatum.Amygdala.Stage 1
Cortex or amygdala or brainstem.Striatum or cortex or brainstem.Stage 2
Striatum + amygdala + cortex or striatum + amygdala + brainstem.Striatum + amygdala + cortex or striatum + amygdala + brainstem or amygdala + cortex + brainstem.Stage 3
All regions.All regions.Stage 4
  • AD, Alzheimer’s disease; AGD, argyrophilic grain disease; CA, cornu ammonis; CBD, corticobasal degeneration; GM ARTAG, grey matter ageing-related tau astrogliopathy; PSP, progressive supranuclear palsy.