Table 1

Proportion of negative BRCA1 expression according to cut-off

Cut-offHistologyTumour typeStudies (n)Total (n)Negative BRCA1 (n)Negative BRCA1 (%)
10%MixedSporadic8128264950.62
MixedSporadic and hereditary or familial3723954.17
MixedUnknown758829650.34
SerousUnknown438314237.08
HGSCSporadic and hereditary or familial229111037.80
PPSCSporadic and hereditary or familial114214.28
Sub-total252630123847.07
5%HGSCSporadic and hereditary or familial11715.88
HGSCUnknown232725277.06
EndometrioidUnknown1453066.67
Sub-total438928372.75
1%MixedSporadic and hereditary or familial21808245.55
AnyMixedSporadic343120748.03
MixedSporadic and hereditary or familial21937126.78
MixedUnknown334822163.50
Sub-total897249951.34
H-score ≥47MixedUnknown1282382.14
H-score >70HGSCSporadic113911784.2
  • HGSC, High-grade serous carcinoma; PPSC, Primary peritoneal serous cancer.