Table 1

Proportion of negative BRCA1 expression according to cut-off

Cut-off	Histology	Tumour type	Studies (n)	Total (n)	Negative BRCA1 (n)	Negative BRCA1 (%)
10%	Mixed	Sporadic	8	1282	649	50.62
	Mixed	Sporadic and hereditary or familial	3	72	39	54.17
	Mixed	Unknown	7	588	296	50.34
	Serous	Unknown	4	383	142	37.08
	HGSC	Sporadic and hereditary or familial	2	291	110	37.80
	PPSC	Sporadic and hereditary or familial	1	14	2	14.28
	Sub-total		25	2630	1238	47.07
5%	HGSC	Sporadic and hereditary or familial	1	17	1	5.88
	HGSC	Unknown	2	327	252	77.06
	Endometrioid	Unknown	1	45	30	66.67
	Sub-total		4	389	283	72.75
1%	Mixed	Sporadic and hereditary or familial	2	180	82	45.55
Any	Mixed	Sporadic	3	431	207	48.03
	Mixed	Sporadic and hereditary or familial	2	193	71	26.78
	Mixed	Unknown	3	348	221	63.50
	Sub-total		8	972	499	51.34
H-score ≥47	Mixed	Unknown	1	28	23	82.14
H-score >70	HGSC	Sporadic	1	139	117	84.2