Table 2

Proportion of BRCA2 negative expression according to cut-off.

Cut-offHistologyTumour typeStudies (n)Total (n)Negative BRCA2 (n)Negative BRCA2 (%)
10%MixedSporadic11154942.50
MixedSporadic and hereditary or familial218211.10
MixedUnknown221511553.50
HGSCSporadic11565334.00
PPSCSporadic and hereditary or familial114000.00
Subtotal751821942.30
5%MixedUnknown127421879.50
≥2 scoreMixedUnknown120917684.00
≥4 scoreHGSCUnknown115012382.00
  • HGSC, High-grade serous carcinoma; PPSC, Primary peritoneal serous cancer.