Proportion of BRCA2 negative expression according to cut-off.
Cut-off | Histology | Tumour type | Studies (n) | Total (n) | Negative BRCA2 (n) | Negative BRCA2 (%) |
10% | Mixed | Sporadic | 1 | 115 | 49 | 42.50 |
Mixed | Sporadic and hereditary or familial | 2 | 18 | 2 | 11.10 | |
Mixed | Unknown | 2 | 215 | 115 | 53.50 | |
HGSC | Sporadic | 1 | 156 | 53 | 34.00 | |
PPSC | Sporadic and hereditary or familial | 1 | 14 | 0 | 00.00 | |
Subtotal | 7 | 518 | 219 | 42.30 | ||
5% | Mixed | Unknown | 1 | 274 | 218 | 79.50 |
≥2 score | Mixed | Unknown | 1 | 209 | 176 | 84.00 |
≥4 score | HGSC | Unknown | 1 | 150 | 123 | 82.00 |
HGSC, High-grade serous carcinoma; PPSC, Primary peritoneal serous cancer.