Reference | Cases examined (n) | Mean number of IgG4-positive cells/HPF | Mean IgG4/IgG ratio | Cases with IgG4:IgG ˃40% | Anatomical sites of cases with IgG4:IgG ˃40% |
Kuo et al 79 | 12 | 117 (range 21–204) | 34% (range 16%–51%) | 3 (25%) | Cutaneous |
Menon et al 80 | 70 | 103* (range 10–350) | 39%* (range 5%–97%) | 12 (17%) | Lymph node (7), salivary gland (1)†, renal (1), mesenteric (1), nasal (1), dural (1), subcutaneous (1) |
Zhang et al 81 | 26 | 39.7 nodal (±11) 22.5 extranodal (±4.6) | 27.9% nodal 33.7% extranodal | 8 (30%) | Nodal (5), extranodal (3) |
Shrestha et al 82 | 8 | 66.8 (range 0–224) | 27.5% (range 0%–70%) | 3 (37.5%) | Nodal (2), soft tissue (1) |
Roberts and Attanoos84 | 1 | Between 11 and 30 | Not provided | – | Lung |
El-Kersh et al 83 | 1 | ‘Significant’—not further specified | Not provided | – | Lung |
Richter et al 87 | 1 | ‘Not increased’—not further specified | Not provided | – | Heart |
Liu et al 86 | 29 | 13.2 (range 5.2–32.6) | 21% (range 11%–34%) | 3 (10%) | Nodal, thyroid, skin |
Chen and Lee88 | 1 | 121 | 33% | – | Parotid |
HPF defined as 0.06 mm2 by all reports.
The IgG4 to IgG ratio of more than 40% is included based on the IgG4 consensus guidelines.
*Mean calculated from the data available for the 29 cases that had elevated levels of IgG4-positive plasma cells.
†One case had lymph node and salivary gland involvement, with both sites showing IgG4 to IgG ratio >40%.
HPF, high power field; RDD, Rosai-Dorfman-Destombes disease.