Neoplasms associated with Lynch syndrome4 13 30
| Cancer type | Notes |
| Gastrointestinal | |
| Colorectal carcinoma (CRC)* | Accounts for 3%–5% of all CRC |
| Gastric adenocarcinoma | |
| Small intestinal adenocarcinoma | |
| Pancreatic adenocarcinoma | |
| Cholangiocarcinoma | |
| Gynaecological | |
| Endometrial carcinoma* | Accounts for 2%–3% of all endometrial cancers |
| Ovarian carcinoma | |
| Other sites | |
| Urinary tract carcinoma (transitional cell) | |
| Prostatic carcinoma | |
| Cutaneous sebaceous tumours† | Muir-Torre syndrome |
| Glioblastoma | |
| Adrenocortical carcinoma | |
| Germ cell tumours | |
| Mesothelioma | |
| Melanoma | |
| Sarcoma | |
*CRC and endometrial carcinoma are the two neoplasms most commonly associated with Lynch syndrome.
†There is also an increased risk of development of keratoacanthoma.