Table 1

The information of cell line mutations

No.GeneAA variationNA variationCosmic numberCell lineMutation rate
1 KRAS p.G12Dc.35G>ACOSM521LS18045.52%
2 KRAS p.G12Cc.34G>TCOSM516NCI-H2375.32%
3 KRAS p.G12Ac.35G>CCOSM522SW111661.65%
4 KRAS p.G13Dc.38G>ACOSM532HCT-1546.41%
5 KRAS p.G12Sc.34G>ACOSM517A549100.00%
6 KRAS p.G13Cc.37G>TCOSM527NCl-H135547.04%
7 NRAS p.Q61Kc.181C>ACOSM580NCI-H208730.35%
8 NRAS p.Q61Rc.182A>GCOSM584NCI-H234799.88%
9 BRAF p.V600Ec.1799T>ACOSM476A205830.19%
10 BRAF p.G469Ac.1406G>CCOSM460NCI-H139596.63%
11 BRAF p.L597Vc.1789C>GCOSM470NCI-H208738.76%
12 PIK3CA p.E542Kc.1624G>ACOSM760T8471.10%
13 PIK3CA p.E545Kc.1633G>ACOSM763NCI-H59647.98%
14 PIK3CA p.H1047Rc.3140A>GCOSM94986MDA-MB-45366.50%
15 PIK3CA p.H1047Lc.3140A>TCOSM776GP2D48.00%
16 EGFR p.T790Mc.2369C>TCOSM6240NCI-H197575.78%
17 EGFR p.G719Sc.2155G>ACOSM6252SW4828.77%
18 EGFR p.L858Rc.2573_2574delTGinsGTCOSM12429NCI-H197570.50%
19 EGFR p.E746_A750delc.2236_2250del15COSM6225HCC82760.06%
20 EGFR p.L747_E749delc.2239_2247delTTAAGAGAACOSM6218HCC 400662.49%
21 EGFR p.E746_S752>Ic.2235_2255>AATCOSM12385HCC 293516.17%
22 EGFR Gain//HCC8274–5 copy
23 MET Gain//Hs 746T2–5 copy
  • AA, amino acid; BRAF, B-type Raf kinase; EGFR, epidermal growth factor receptor; KRAS, kirsten rat sarcoma viral oncogene; MET, mesenchymal-epithelial transition factor; NA, nucleotide residue; NRAS, neuroblastoma ras oncogene; PIK3CA, phosphatidylinositol-4,5-bisphosphate3-kinasecatalytic subunit alpha.