Genetic variations in hACE2 detected in the interface between SARS-CoV/SARS-CoV-2 S-protein and hACE2
| SARS-CoV-2 S-protein | SARS-CoV S-protein | hACE2 | Polymorphism in hACE2 | GERP++_RS | phyloP100way_vertebrate | phastCons100way_vertebrate |
| A475, G476 | P462 | S19 | p.Ser19Pro | −0.495 | −0.801 | 0 |
| F456, Y473, A475, Y489 | L443, Y475 | T27 | p.Thr27Ala | 1.85 | 0.345 | 0 |
| Q493 | – | E35 | p.Glu35Lys | −0.741 | −0.368 | 0 |
| p.Glu35Asp | 0.813 | −0.753 | 0.013 | |||
| Y505 | Y491 | E37 | p.Glu37Lys | 5.81 | 2.967 | 0.995 |
| F486 | L472 | M82 | p.Met82Ile | −10.4 | −1.463 | 0 |
| – | R426 | E329 | p.Glu329Gly | 2.8 | 1.025 | 0.001 |
| T500, G502 | T486, T487, G488 | D355 | p.Asp355Asn | 5.34 | 7.905 | 1 |
hACE2, human angiotensin-converting enzyme 2; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.