Table 2

Comparison of secondary clinical outcomes in subgroups of COVID-19 severity

Subgroup severityOverallCCP groupControl BOR (95% CI)P value
Ventilatory support(n=68)
25.0 (15.8, 44.5)
(n=34)
23.5 (16.0, 64.3)
(n=34)
28.0 (15.8, 44.0)
1.01 (0.99 to 1.03)0.33
ECMO support28.5 (19.3, 45.8)28.0 (18.0, 55.0)31.0 (21.0, 43.0)1.01 (0.98 to 1.05)0.52
LOS in ICU20.5 (13.3, 33.5)21.0 (13.0, 32.8)20.5 (14.3, 33.5)1.01 (0.99 to 1.03)0.60
LOS in hospital27.5 (16.5, 48.3)28.5 (17.0, 47.3)27.5 (12.5, 47.5)1.01 (0.99 to 1.03)0.23
30 days in-hospital mortality, n (%)17 (25.0)9 (26.5)8 (23.5)1.12 (0.34 to 3.79)1
Non-mechanically ventilated(n=12)(n=6)(n=6)
Ventilatory supportN/AN/AN/AN/AN/A
ECMO supportN/AN/AN/AN/AN/A
LOS in ICU6.0 (4.5, 6.0)6.0 (5.5, 7.0)4.0 (3.0, 5.0)1.83 (0.78 to 9.76)0.30
LOS in hospital11.0 (7.0, 17.0)17.0 (13.3, 17.8)7.5 (6.3, 9.5)1.43 (1.06 to 2.39)0.07
30 days in-hospital mortality, n (%)N/AN/AN/AN/AN/A
Mechanically ventilated(n=34)(n=17)(n=17)
Ventilatory support18.0 (13.0, 28.8)18.0 (13.0, 25.0)18.0 (7.0, 31.0)1.01 (0.97 to 1.05)0.64
ECMO supportN/AN/AN/ANANA
LOS in ICU18.0 (13.0, 25.3)18.0 (13.0, 26.0)20.0 (10.0, 23.0)1.00 (0.96 to 1.05)0.98
LOS in hospital27.0(15.5, 39.5)27.0 (17.0, 41.0)27.0 (15.0, 37.0)1.01 (0.97 to 1.04)0.68
30 days in-hospital mortality, n (%)13 (38.2)7 (41.2)6 (35.3)1.16 (0.27 to 5.17)1
ECMO(n=22)(n=11)(n=11)
Ventilatory support45.0 (31.0, 67.8)65.0 (29.5, 70.5)44.0 (32.5, 54.5)1.02 (0.99 to 1.07)0.26
ECMO support28.5 (19.3, 45.8)28.0 (18.0, 55.0)31.0 (21.0, 43.0)1.01 (0.98 to 1.05)0.52
LOS in ICU36.5 (25.0, 63.8)38.0 (25.0, 70.0)35.0 (25.5, 50.0)1.02 (0.99 to 1.06)0.29
LOS in hospital50.5 (31.3, 69.8)68.0 (29.0, 88.5)48.0 (36.0, 59.0)1.02 (0.99 to 1.06)0.25
30 days in-hospital mortality, n (%)4 (18.2)2 (18.2)2 (18.2)1.00 (0.06 to 16.14)1
  • Values are number of days as median (IQR).

  • Analysis of statistically significant differences between groups performed using an OR test with Wald 95% CIs.

  • CCP, convalescent plasma; ECMO, extracorporeal membrane oxygenation; ICU, intensive care unit; LOS, length of stay; N/A, not available.