Table 1

Demographics and clinical characteristics

Overall (n=129)CCP group (n=34)Control A (n=68)Control B (n=34)P value CCP vs AP value CCP vs B
Male sex, n (%)*88 (68.2)23 (67.6)46 (67.6)23 (67.6)11
Age (years), mean (SD)†57.4 (16.4)55.4 (16.6)59.0 (16.8)57.2 (15.3)0.310.65
Comorbidities, n (%)*
BMI >3025 (19.4)6 (17.6)18 (26.5)4 (11.8)0.460.73
Diabetes50 (38.8)14 (41.2)28 (41.2)12 (35.3)1.000.80
Hypertension67 (51.9)16 (47.1)38 (55.9)17 (50.0)0.411.00
Chronic obstructive pulmonary disease10 (7.8)3 (8.8)7 (10.3)2 (5.9)1.001.00
Chronic kidney disease14 (10.9)2 (5.9)11 (16.2)1 (2.9)0.211.00
Hyperlipidaemia36 (27.9)7 (20.6)27 (39.7)4 (11.8)0.070.51
Coronary artery disease8 (6.2)1 (2.9)6 (8.8)3 (8.8)0.420.61
Other therapies2 (1.6)2 (5.9)0 (0.0)0 (0.0)0.110.49
Symptoms, n (%)*
Dyspnoea118 (91.5)32 (94.1)59 (86.8)33 (97.1)0.331.00
SpO2 <93%107 (82.9)28 (82.4)51 (75.0)34 (100.0)0.460.03
Respiratory rate >3074 (57.4)19 (55.9)33 (48.5)24 (70.6)0.530.31
Arterial O2/FiO2 <300107 (82.9)34 (100.0)45 (66.2)33 (97.1)<0.0011.00
Respiratory failure109 (84.5)34 (100.0)47 (69.1)34 (100.0)<0.0011.00
Septic shock48 (37.2)15 (44.1)25 (36.8)13 (38.2)0.520.81
Disease severity n (%)*0.0011
Non-ventilated39 (30.2)6 (17.6)29 (42.6)6 (17.6)
Mechanical ventilation65 (50.4)17 (50.0)35 (51.5)17 (50.0)
ECMO25 (19.4)11 (32.4)4 (5.9)11 (32.4)
ABO, n (%)*<0.0010.002
 A neg4 (3.1)0 (0.0)3 (4.4)2 (5.9)
 A pos30 (23.3)6 (17.6)17 (25.0)9 (26.5)
 AB pos2 (1.6)0 (0.0)2 (2.9)0 (0.0)
 B neg1 (0.8)0 (0.0)1 (1.5)0 (0.0)
 B pos20 (15.5)8 (23.5)10 (14.7)2 (5.9)
 O neg1 (0.8)0 (0.0)1 (1.5)0 (0.0)
 O pos45 (34.9)20 (58.8)14 (20.6)13 (38.2)
 N/A26 (20.2)0 (0.0)20 (29.4)8 (23.5)
Other therapies, n (%)*
Hydroxychloroquine70 (54.3)18 (52.9)39 (57.4)19 (55.9)0.681.00
Azithromycin54 (41.9)9 (26.5)38 (55.9)12 (35.3)0.010.60
Steroids21 (16.3)11 (32.4)2 (2.9)8 (23.5)<0.0010.59
Tocilizumab30 (23.3)14 (41.2)10 (14.7)7 (20.6)0.010.11
Remdesivir25 (19.4)7 (20.6)11 (16.2)7 (20.6)0.591
Stem cells4 (3.1)0 (0.0)3 (4.4)2 (5.9)0.550.49
  • ABO: Blood type

  • *Fisher’s exact test.

  • †Welch’s one-way ANOVA.

  • ANOVA, analysis of variance; BMI, body mass index; CCP, convalescent plasma; ECMO, extracorporeal membrane oxygenation; FiO2, fractional inspired oxygen; N/A, not available; SpO2, oxygen saturation.