Table 1

CD45 biological functions and disorders associated with altered CD45 function

CD45-dependant cellular physiologyCD45 functionAltered CD45
Expression consequences
T and B-lymphocytes activation, development, tolerance and survival2 Regulation of SFK activity by dephosphorylating the C-terminal negative regulatory tyrosine2
Initiation of TCR signalling2
T- and B- cell dysfunction2
Affect immune cell adhesion and migration2
Autoimmune infectious diseases2
HIV2
Downstream of JNK and P38 pathway41 Modulation of cytokine and chemokine production and signalling14
Recruitment of DOK-1 to the proximal plasma membrane42
Severe combined immunodeficiency43
Negatively regulator monocytic cell differentiation44
Regulate FLT3 signalling in vivo45
Inhibiting phorbol 12-myristate 13-acetate-dependent activation and tyrosine phosphorylation of protein kinase C44 Acute myeloid leukaemia45
Myeloproliferative neoplasm45
Cortical porosity45
Ectopic bone formation45
Increased cell movement15 Regulation of calcium NF-AT TCA pathway46 Decreased Insulin receptor signalling results in defective cellular motility due to reduction of matrix metalloproteinase secretion15
  • JNK, Janus kinases; NF-AT, nuclear factor of activated T cells; SFK, Src family kinase; TCA, T cell activation; TCR, T cell receptor.