Table 1

Epidemiological details and immunohistochemistry results for ependymoma separated by molecular profile and anatomical compartment

CasesPrimary,
recurrence
Mean age (range)F/MTumour grades I–IIIL1CAM posNfkappaB p65 posYAP1 posPAX6 mean
% (range)
EPN-RELA105/522.5 (3–42)2/80-0-106/88/87/717.1 (1.9–38.3)
EPN-YAP121/12 (1–3)1/10-0-20/20/21/241 (6.3–75.6)
SE-SUP55/050.8 (40–66)2/35-0-00/50/54/56.7 (0.7–19.6)
PFA169/77.5 (2–42)6/100-5-111/81/75/632.8 (1–95.6)
PFB2420/445.2 (20–77)11/130-17-70/230/2322/2329.3 (0.5–94)
SE-INF55/061.6 (47–75)0/55-0-00/50/53/43.4 (0.7–10.7)
MPE2927/238.4 (9–60)11/1829-0-00/270/2818/2630.9 (2.9–78.5)
EPN-SPINE6864/447.1 (11–82)33/350-63-52/652/6648/5931 (0.4–97.5)
EPN-NC1311/240,61 (2–74)3/100-6-70/120/123/1215 (0–61.3)
  • EPN-NC, not classified; EPN-RELA, ependymoma RELA-fusion positive; EPN-SPINE, spinal ependymoma; EPN-YAP1, ependymoma with Yap1 fusion; MPE, myxopapillary ependymoma; PAX6, paired box 6; PFA, posterior fossa group A ; PFB, posterior fossa group B ependymoma; SE-INF, subependymoma infratentorial; SE-SUP, subependymoma supratentorial.