Results of single variable Cox proportional hazard models with overall survival (OS) and progression-free survival (PFS) as outcome
| Explanatory variable | OS | PFS | ||
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Sex (male) | 2.95 (1.12 to 7.79) | 0.022 | 3.30 (1.27 to 8.53) | 0.009 |
| Age | 1.04 (1.00 to 1.08) | 0.041 | 1.04 (1.00 to 1.08) | 0.018 |
| MYC translocation | – | 0.328 | 0.387 | |
| BCL2 translocation | – | 0.089 | 0.087 | |
| Double hit (Yes) | 3.46 (0.79 to 15.13) | 0.157 | 3.79 (0.84 to 17.16) | 0.139 |
| MYC expression (≥40%) | – | 0.708 | – | 0.577 |
| BCL2 expression (≥70%) | – | 0.512 | – | 0.407 |
| MYC expression ≥60% BCL2 ≥50% | – | 0.078 | 2.83 (1.12 to 7.20) | 0.035 |
| MYC expression ≥60% BCL2 ≥70% | – | 0.093 | 2.84 (1.10 to 7.36) | 0.041 |
| Ki-67 expression (≥90%) | – | 0.797 | – | 0.868 |
| Relapsed refractory | 3.34 (1.35 to 8.30) | 0.012 | NA | NA |
| R-containing therapy | 0.22 (0.08 to 0.57) | 0.006 | 0.27 (0.10 to 0.73) | 0.018 |
| IPI score (≥3) | 8.82 (2.01 to 38.78) | <0.001 | 4.66 (1.53 to 14.19) | 0.003 |
| Ann Arbor staging (≥3) | – | 0.584 | – | 0.406 |
| ECOG status (≥3) | 3.67 (1.48 to 9.07) | 0.001 | 4.09 (1.63 to 10.24) | 0.004 |
| GCB | – | 0.113 | 0.33 (0.12 to 0.91) | 0.039 |
The table reports the HR in terms of increased risk of death and/or progression event. p values highlighted in bold are statistically significant.
ECOG, Eastern Cooperative Oncology Group; GCB, germinal centre B-cell; IPI, International Prognostic Index; NA, not applicable.