Table 1

Clinical, histopathological and molecular features of case series with MDM2 and PD-L1 status

Patient	Sex	Age	pT stage	Molecular classification	MDM2 status	PD-L1 status
pT2-T3 bladder UC without lymph node metastases (N0)
1	F	72	T2	Luminal-papillary	Amplification	≥50%
2	M	71	T2	Luminal-papillary	Gains/polyploidy	Absent
3	F	79	T2	Luminal-papillary	Disomy	Absent
4	M	68	T2	Luminal-papillary	Disomy	≥1% <50%
5	F	66	T3	Luminal-papillary	Disomy	≥1% <50%
6	M	85	T2	Luminal-papillary	Disomy	Absent
7	F	73	T2	Luminal-papillary	Disomy	Absent
8	M	79	T2	Luminal-papillary	Disomy	Absent
9	F	74	T3	Luminal non-specified	Amplification	Absent
10	M	67	T2	Luminal non-specified	Gains/polyploidy	≥1% <50%
11	F	60	T2	Luminal non-specified	Disomy	Absent
12	F	84	T3	Luminal unstable	Amplification	≥1% <50%
13	M	70	T3	Luminal unstable	Gains/polyploidy	Absent
14	M	58	T2	Luminal unstable	Disomy	≥1% <50%
15	M	69	T2	Luminal unstable	Disomy	Absent
16	M	85	T2	Luminal unstable	Disomy	Absent
17	F	75	T2	luminal unstable	Disomy	Absent
18	M	69	T2	Stroma-rich	Amplification	Absent
19	M	79	T3	Stroma-rich	Gains/polyploidy	Absent
20	M	74	T2	Stroma-rich	Disomy	≥1% <50%
21	F	61	T2	Stroma-rich	Disomy	≥1% <50%
22	M	85	T2	Stroma-rich	Disomy	Absent
23	M	82	T3	Stroma-rich	Disomy	Absent
24	M	56	T2	Basal-squamous	Amplification	≥1% <50%
25	M	87	T3	Basal-squamous	Disomy	≥1% <50%
26	F	85	T2	Basal-squamous	Disomy	≥1% <50%
27	M	88	T2	Basal-squamous	Disomy	Absent
28	M	78	T2	Basal-squamous	Disomy	≥50%
29	M	74	T3	Basal-squamous	Disomy	Absent
30	M	67	T3	Basal-squamous	Disomy	Absent
31	F	76	T3	Basal-squamous	Disomy	Absent
32	M	78	T3	Basal-squamous	Disomy	Absent
33	M	81	T2	Basal-squamous	Disomy	Absent
34	F	66	T3	Basal-squamous	Disomy	Absent
35	M	67	T3	Basal-squamous	Disomy	Absent
36	F	78	T3	Basal-squamous	Disomy	Absent
37	M	83	T2	Neuroendocrine-like	Disomy	Absent
pT2-T3 bladder UC with lymph node metastases (N+)
38	F	78	T2	Luminal-papillary	Amplification	Absent
39	F	77	T3	Luminal-papillary	Gains/polyploidy	≥1% <50%
40	M	72	T3	Luminal-papillary	Disomy	≥50%
41	F	69	T3	Luminal non-specified	Disomy	Absent
42	M	88	T3	Luminal unstable	Disomy	≥1% <50%
43	F	81	T3	Luminal unstable	Disomy	≥1% <50%
44	M	77	T3	Stroma-rich	Disomy	≥1% <50%
45	M	76	T2	Stroma-rich	Disomy	Absent
46	M	73	T3	Basal-squamous	Disomy	Absent
47	F	74	T3	Basal-squamous	Disomy	Absent
48	F	74	T3	Basal-squamous	Disomy	Absent
49	M	70	T3	Basal-squamous	Disomy	Absent
50	M	71	T2	Neuroendocrine-like	Disomy	Absent

MDM2, murine double minute 2; p, pathological; PD-L1, programmed death ligand 1; UC, urothelial carcinoma.