Univariate analysis of histopathological features of cohort, comparing cribriform carcinoma (CC) against non-CC carcinomas
| CC | All other cases | P value (CC vs other) | |
| n | 33 | 144 | N/A |
| Slides of invasive carcinoma sampled (mean) | 5.75 | 5.30 | 0.3454 |
| Histological grade | |||
| G1 | 2 (6.1%) | 13 (9.0%) | 0.1660 |
| G2 | 30 (90.9%) | 111 (77.1%) | |
| G3 | 1 (3.0%) | 20 (13.9%) | |
| Central comedonecrosis | 29 (87.9%) | 12 (8.3%) | <0.0001* |
| High tumour budding (>10) | 14 (42.4%) | 86 (59.7%) | 0.0816 |
| Prominent desmoplasia | 8 (24.2%) | 72 (50.0%) | 0.0109* |
| Prominent tumour-infiltrating lymphocytes | 0 (0%) | 26 (18.1%) | 0.0050* |
| Crohn-like inflammatory reaction | 10 (30.3%) | 73 (50.7%) | 0.0520 |
| Extramural venous extension | 8 (24.2%) | 9 (6.3%) | 0.0046† |
| Perineural invasion | 3 (9.1%) | 16 (11.1%) | >0.9999 |
| Predominant growth pattern at border | |||
| Nodular (‘pushing’) | 23 (69.7%) | 68 (47.2%) | 0.0230† |
| Both nodular and infiltrative | 5 (15.2%) | 18 (12.5%) | |
| Infiltrative | 5 (15.2%) | 58 (40.3%) |
*P<0.05.
†P<0.05 and multivariate analysis described in text.