Univariate and multivariate analyses of OS in all patients
| Variable | Univariate analyses | Multivariate analyses | ||
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Gender | ||||
| Female | 1.000 | 0.400 | ||
| Male | 2.368 (0.318 to 17.644) | |||
| Age (years) | ||||
| ≤75 | 1.000 | 0.102 | ||
| ＞75 | 2.069 (0.865 to 4.949) | |||
| Tumour differentiation | ||||
| Single differentiation | 1.000 | 0.829 | ||
| With other components | 1.177 (0.27 to 5.126) | |||
| Tumour depth | ||||
| T1 | 1.000 | 0.269 | ||
| T2 | 3.904 (0.518 to 29.419) | 0.186 | ||
| T3/4 | 6.629 (0.670 to 65.556) | 0.106 | ||
| LN metastasis | ||||
| Absent | 1.000 | 0.083 | ||
| Present | 2.427 (0.891 to 6.613) | |||
| TNM stage | ||||
| I–II | 1.000 | 0.026 | 1.000 | 0.041 |
| III–IV | 2.713 (1.124 to 6.547) | 2.570 (1.041 to 6.346) | ||
| TILs | ||||
| Absent | 1.000 | 0.079 | 1.000 | 0.031 |
| Present | 2.291 (0.91 to 5.768) | 3.699 (1.125 to 12.159) | ||
| T-PD-L1 (5% cut-off value) | ||||
| Negative | 1.000 | 0.130 | 1.000 | 0.682 |
| Positive | 1.932 (0.823 to 4.533) | 1.240 (0.443 to 3.467) | ||
| I-PD-L1 (1% cut-off value) | ||||
| Negative | 1.000 | 0.382 | 1.000 | 0.026 |
| Positive | 0.683 (0.291 to 1.605) | 0.336 (0.129 to 0.876) | ||
OS, overall survival; TILs, tumour infiltrating lymphocytes.