Multivariate Cox regression for prediction of 30-day mortality, requirement of critical care, NIV and intubation and ventilation using biomarkers in baseline bloods
| Biomarker | Patients (N) | Cases (N) | Wald | D.F. | C-index (95% CI) | HR (95% CI) | P value |
| Prediction of 30-day mortality | |||||||
| MR-proADM | 135 | 30 | 23.736 | 5 | 0.827 (0.756 to 0.898) | 1.8709 (1.454 to 2.407) | 1.1e−6 |
| CRP | 135 | 30 | 12.166 | 5 | 0.788 (0.704 to 0.872) | 1.0069 (1.003 to 1.011) | 0.000487 |
| PCT | 116 | 26 | – | – | – | – | – |
| Neutrophils | 135 | 30 | 0.9235 | 5 | 0.808 (0.745 to 0.871) | 0.9445 (0.841 to 1.061) | 0.336 303 |
| Lymphocytes | 135 | 30 | 6.6564 | 5 | 0.791 (0.713 to 0.869) | 1.1213 (1.028 to 1.223) | 0.009879 |
| Prediction of requiring critical care admission | |||||||
| MR-proADM | 135 | 31 | 10.151 | 5 | 0.713 (0.621 to 0.805) | 1.5451 (1.182 to 2.019) | 0.00144 |
| CRP | 135 | 31 | 22.062 | 4 | 0.775 (0.702 to 0.848) | 1.0078 (1.005 to 1.011) | 2.64e−6 |
| PCT | 116 | 31 | 0.6084 | 5 | 0.715 (0.631 to 0.799) | 1.0254 (0.963 to 1.092) | 0.43 564 |
| Neutrophils | 135 | 31 | 0.5761 | 5 | 0.686 (0.596 to 0.776) | 1.0221 (0.966 to 1.081) | 0.44 772 |
| Lymphocytes | 135 | 31 | 1.4066 | 5 | 0.689 (0.599 to 0.779) | 1.0638 (0.961 to 1.178) | 0.23 544 |
| Prediction of requiring NIV | |||||||
| MR-proADM | 135 | 23 | 30.393 | 5 | 0.828 (0.740 to 0.916) | 2.5230 (1.816 to 3.506) | 3.53e−8 |
| CRP | 135 | 23 | 18.293 | 5 | 0.799 (0.725 to 0.873) | 1.0081 (1.004 to 1.012) | 1.89e−5 |
| PCT | 116 | 22 | 1.39 | 5 | 0.755 (0.659 to 0.851) | 1.0454 (0.971 to 1.125) | 0.2383 |
| Neutrophils | 135 | 23 | 0.0266 | 5 | 0.72 (0.616 to 0.824) | 0.9923 (0.905 to 1.089) | 0.8706 |
| Lymphocytes | 135 | 23 | – | – | – | – | – |
| Prediction of intubation and ventilation | |||||||
| MR-proADM | 135 | 16 | 22.648 | 5 | 0.793 (0.687 to 0.899) | 2.2457 (1.609 to 3.134) | 1.94e−6 |
| CRP | 135 | 16 | 18.318 | 5 | 0.803 (0.713 to 0.893) | 1.0088 (1.005 to 1.013) | 1.87e−5 |
| PCT | 116 | 16 | 2.241 | 5 | 0.715 (0.617 to 0.813) | 1.0558 (0.983 to 1.134) | 0.134 |
| Neutrophils | 135 | 16 | 0.4543 | 5 | 0.665 (0.563 to 0.767) | 1.0254 (0.953 to 1.103) | 0.500 |
| Lymphocytes | 135 | 16 | 0.2663 | 5 | 0.67 (0.554 to 0.786) | 0.8260 (0.400 to 1.707) | 0.606 |
CRP, C reactive protein; D.F., Degrees of Freedom; MR-proADM, mid-regional proadrenomedullin; NIV, non-invasive ventilation; PCT, procalcitonin.