Univariate Cox regression for prediction of 30-day mortality, requirement of critical care, NIV and intubation and ventilation using biomarkers in baseline bloods
| Biomarker | Patients (N) | Cases (N) | Wald | D.F. | C-index (95% CI) | HR (95% CI) | P value |
| Prediction of 30-day mortality | |||||||
| MR-proADM | 135 | 30 | 20.3 | 1 | 0.811 (0.746 to 0.876) | 1.5455 (1.279 to 1.868) | 6.64e−6 |
| CRP | 135 | 30 | 4.02 | 1 | 0.613 (0.515 to 0.711) | 1.0034 (1.000 to 1.007) | 0.0449 |
| PCT | 116 | 26 | 11.54 | 1 | 0.621 (0.511 to 0.731) | 1.0898 (1.037 to 1.145) | 0.000681 |
| Neutrophils | 135 | 30 | 0.73 | 1 | 0.549 (0.445 to 0.653) | 0.9555 (0.861 to 1.061) | 0.394 |
| Lymphocytes | 135 | 30 | 3.53 | 1 | 0.448 (0.338 to 0.558) | 1.0920 (0.996 to 1.197) | 0.0603 |
| Prediction of requiring critical care admission | |||||||
| MR-proADM | 135 | 31 | 3.2 | 1 | 0.614 (0.518 to 0.710) | 1.2570 (0.978 to 1.615) | 0.0737 |
| CRP | 135 | 31 | 15.83 | 1 | 0.716 (0.624 to 0.808) | 1.0055 (1.003 to 1.008) | 0.0000695 |
| PCT | 116 | 31 | 0.03 | 1 | 0.687 (0.595 to 0.779) | 1.0050 (0.951 to 1.062) | 0.86 |
| Neutrophils | 135 | 31 | 0.37 | 1 | 0.609 (0.511 to 0.707) | 1.0183 (0.960 to 1.080) | 0.544 |
| Lymphocytes | 135 | 31 | 2.52 | 1 | 0.465 (0.357 to 0.573) | 1.0759 (0.983 to 1.178) | 0.113 |
| Prediction of requiring NIV | |||||||
| MR-proADM | 135 | 23 | 11.62 | 1 | 0.726 (0.634 to 0.818) | 1.4992 (1.188 to 1.892) | 0.000651 |
| CRP | 135 | 23 | 15.53 | 1 | 0.725 (0.617 to 0.833) | 1.0061 (1.003 to 1.009) | 0.0000813 |
| PCT | 116 | 22 | 0.1 | 1 | 0.772 (0.682 to 0.862) | 1.0098 (0.952 to 1.072) | 0.747 |
| Neutrophils | 135 | 23 | 0.06 | 1 | 0.432 (0.324 to 0.540) | 0.9883(0.901 to 1.085) | 0.804 |
| Lymphocytes | 135 | 23 | 4.81 | 1 | 0.552 (0.442 to 0.662) | 1.0991 (1.010 to 1.196) | 0.0283 |
| Prediction of intubation and ventilation | |||||||
| MR-proADM | 135 | 16 | 12.37 | 1 | 0.748 (0.650 to 0.846) | 1.6015 (1.232 to 2.082) | 0.000435 |
| CRP | 135 | 16 | 16.57 | 1 | 0.745 (0.614 to 0.876) | 1.0069 (1.004 to 1.010) | 0.0000469 |
| PCT | 116 | 16 | 0.63 | 1 | 0.836 (0.746 to 0.926) | 1.0215 (0.969 to 1.077) | 0.429 |
| Neutrophils | 135 | 16 | 0.43 | 1 | 0.641 (0.514 to 0.768) | 1.0259 (0.950 to 1.107) | 0.513 |
| Lymphocytes | 135 | 16 | 0.09 | 1 | 0.468 (0.337 to 0.599) | 0.9415 (0.630 to 1.408) | 0.769 |
CRP, C reactive protein; D.F., Degrees of Freedom; MR-proADM, mid-regional proadrenomedullin; NIV, non-invasive ventilation; PCT, procalcitonin.