Table 1

Metrics for Alb-ISH and CRP immunohistochemistry (threshold immunoreactive score=1) as diagnostic markers for iCCA

SensitivitySpecificity
Alb-ISH69.5%98.8%
CRP immunohistochemistry84.1%86.4%
Alb-ISH and CRP*88.0%86.1%
  • *For combined assessment of Alb-ISH and CRP, positivity of a single marker was considered sufficient for a diagnosis of iCCA (ie, diagnosis rejection required conegativity).

  • Alb-ISH, albumin in situ hybridisation; CRP, C reactive protein; iCCA, intrahepatic cholangiocarcinoma.