Clinicopathological characteristics of intrahepatic cholangiocarcinoma patients stratified for CRP immunohistochemistry
| Total | CRP neg. | CRP pos. | P value | ||
| All patients | 151 | 24 | 127 | ||
| Age | Median | 62.2 | 61.5 | 62.6 | 0.344 |
| IQR | 54.0–69.7 | 47.4–66.8 | 54.0–69.8 | ||
| Sex | Male | 84 | 14 (58.3) | 70 (55.1) | 0.826 |
| Female | 67 | 10 (41.7) | 57 (44.9) | ||
| Histology | Ductal | 77 | 12 (50.0) | 65 (51.2) | 0.066* |
| Solid | 51 | 3 (12.5) | 48 (37.8) | ||
| Papillary | 9 | 2 (8.3) | 7 (5.5) | ||
| Clear cell | 7 | 2 (8.3) | 5 (3.9) | ||
| Mucinous | 3 | 3 (12.5) | 0 (0.0) | ||
| Signet ring | 3 | 2 (8.3) | 1 (0.8) | ||
| Adenosquamous | 1 | 0 (0.0) | 1 (0.8) | ||
| Subtype | Small duct | 91 | 7 (29.2) | 84 (66.1) | 0.001 |
| Large duct | 60 | 17 (70.8) | 43 (33.9) | ||
| UICC | UICC 1 | 5 | 0 (0.0) | 5 (7.7) | 0.047† |
| UICC 2 | 30 | 3 (18.8) | 27 (41.5) | ||
| UICC 3 | 41 | 12 (75.0) | 29 (44.6) | ||
| UICC 4 | 5 | 1 (6.2) | 4 (6.2) | ||
| NA | 70 | 8 | 62 | ||
| pT | T1 | 19 | 4 (16.7) | 15 (11.8) | 0.320‡ |
| T2 | 90 | 11 (45.8) | 79 (62.2) | ||
| T3 | 26 | 6 (25.0) | 20 (15.8) | ||
| T4 | 16 | 3 (12.5) | 13 (10.2) | ||
| pN | N0 | 46 | 7 (43.8) | 39 (60.9) | 0.263 |
| N1 | 34 | 9 (56.2) | 25 (39.1) | ||
| NX | 71 | 8 | 63 | ||
| M | M0 | 146 | 23 (95.8) | 123 (96.9) | 0.585 |
| M1 | 5 | 1 (4.2) | 4 (3.1) | ||
| G | G1 | 7 | 0 (0.0) | 7 (5.5) | 0.464§ |
| G2 | 100 | 19 (79.2) | 81 (63.8) | ||
| G3 | 44 | 5 (20.8) | 39 (30.7) | ||
| R | R0 | 83 | 8 (42.1) | 75 (66.4) | 0.070¶ |
| R1 | 46 | 11 (57.9) | 35 (31.0) | ||
| R2 | 3 | 0 (0.0) | 3 (2.6) | ||
| RX | 19 | 5 | 14 | ||
| L | L0 | 70 | 13 (54.2) | 57 (44.9) | 0.504 |
| L1 | 81 | 11 (45.8) | 70 (55.1) | ||
| V | V0 | 43 | 11 (45.8) | 32 (25.2) | 0.0498 |
| V1 | 108 | 13 (54.2) | 95 (74.8) | ||
| Pn | Pn0 | 112 | 16 (66.7) | 96 (75.6) | 0.445 |
| Pn1 | 39 | 8 (33.3) | 31 (24.4) | ||
| Overall survival | Median survival in years (n) | 4.2 (131) | 3.2 (21) | 5.2 (110) | . |
Unless otherwise noted, data are depicted as absolute numbers (%). P values were calculated using Fisher’s exact test excluding missing data (NA, NX, RX). Bold p values denote statistical significance.
To achieve sufficient group sizes for statistical analysis, subgroups were pooled for selected criteria and comparisons carried out as follows:
*Ductal+mucinous+signet ring+papillary versus solid+adenosquamous+clear cell.
†UICC1+2 versus UICC3+4.
‡pT1+2 versus pT3+4.
§G1+2 versus G3.
¶R0 versus R1+2.
CRP neg./pos., C reactive protein negative/positive; G, grade of differentiation; L/V, invasion into lymphatic or blood vessels; M, distant metastases; pN, histopathologic lymph node evaluation; Pn, perineural invasion; pT, histopathologic tumour stage evaluation; R, resection margins; UICC 1–4, Union for International Cancer Control stages 0–4.