Univariate and multivariate Cox regression analyses for CRC prognostics
| Clinicopathological characteristics | Cox univariate analysis | Cox multivariate analysis | ||
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age (≥50 years vs <50 years) | 1.264 (1.162 to 1.375) | <0.001 | 1.394 (1.212 to 1.603) | <0.001 |
| Gender (female vs male) | 0.939 (0.880 to 1.001) | 0.055 | 1.000 (0.899 to 1.113) | 0.999 |
| Mucinous subtype (positive vs negative) | 1.271 (1.144 to 1.412) | <0.001 | 1.033 (0.853 to 1.253) | 0.737 |
| Tumour differentiation (poor vs moderately well) | 1.972 (1.845 to 2.108) | <0.001 | 1.300 (1.154 to 1.465) | <0.001 |
| Lymphovascular invasion (positive vs negative) | 2.471 (2.318 to 2.633) | <0.001 | 1.398 (1.241 to 1.575) | <0.001 |
| Perineural invasion (positive vs negative) | 2.272 (2.129 to 2.424) | <0.001 | 1.573 (1.406 to 1.761) | <0.001 |
| Circumferential resection margin (positive vs negative) | 4.303 (3.695 to 5.012) | <0.001 | 2.407 (1.834 to 3.160) | <0.001 |
| Tumour size (≥4 cm vs <4 cm) | 1.231 (1.152 to 1.315) | <0.001 | 1.279 (1.143 to 1.432) | <0.001 |
| T stage (T2, T3 and T4 vs Tis and T1) | 3.086 (2.428 to 3.922) | <0.001 | 1.312 (0.859 to 2.005) | 0.208 |
| N stage (N1 and N2 vs N0) | 3.150 (2.938 to 3.378) | <0.001 | 1.720 (1.504 to 1.967) | <0.001 |
| M stage (M1 vs M0) | 6.252 (5.839 to 6.694) | <0.001 | 4.470 (3.979 to 5.022) | <0.001 |
| TNM stage (II, III and IV vs 0 and I) | 3.620 (3.163 to 4.143) | <0.001 | 1.464 (1.124 to 1.908) | 0.005 |
| p21 (weakly positive and positive vs negative) | 0.904 (0.844 to 0.968) | 0.004 | 0.816 (0.722 to 0.923) | 0.001 |
| EGFR (weakly positive and positive vs negative) | 1.128 (1.031 to 1.235) | 0.009 | 1.002 (0.900 to 1.115) | 0.977 |