Table 3

Adjusted segmented negative binomial regressions (adjusted for mean centred aggregated bed days)

Test	Time period	Incidence rate ratio	Lower 95% CI	Upper 95% CI	P-value	Type 3 p-value
Overall						0.043*
	Preimplementation	1.004	1.001	1.007
	During-implementation	1.002	0.999	1.004
	Postimplementation	1.007	1.004	1.010
	Postimplementation vs Preimplementation	1.003	0.999	1.007	0.108
	Estimated intervention effect	0.989	0.943	1.037	0.645
UEC						0.090
	Preimplementation	1.003	1.001	1.006
	During-implementation	1.003	1.000	1.005
	Postimplementation	1.008	1.005	1.011
	Postimplementation vs Preimplementation	1.004	1.000	1.008	0.030*
	Estimated intervention effect	0.981	0.938	1.025	0.382
FBC						0.017*
	Preimplementation	1.004	1.001	1.008
	During-implementation	1.001	0.998	1.004
	Postimplementation	1.008	1.005	1.011
	Postimplementation vs Preimplementation	1.004	0.999	1.008	0.092
	Estimated intervention effect	0.976	0.917	1.037	0.429
Troponin						0.640
	Preimplementation	1.009	0.999	1.019
	During-implementation	1.008	0.997	1.019
	Postimplementation	1.001	0.988	1.013
	Postimplementation vs Preimplementation	0.992	0.976	1.008	0.339
	Estimated intervention effect	0.978	0.794	1.207	0.839
TSH						0.005*
	Preimplementation	1.019	1.006	1.033
	During-implementation	0.965	0.954	0.977
	Postimplementation	1.013	1.004	1.022
	Postimplementation vs Preimplementation	0.994	0.978	1.010	0.443
	Estimated intervention effect	0.769	0.600	0.985	0.038*
Vitamin D						0.099
	Preimplementation	1.029	1.011	1.048
	During-implementation	1.003	0.972	1.034
	Postimplementation	0.998	0.982	1.014
	Postimplementation vs Preimplementation	0.969	0.947	0.992	0.010*
	Estimated intervention effect	0.650	0.466	0.907	0.011*
HbA1c						0.242
	Preimplementation	1.001	0.992	1.011
	During-implementation	0.990	0.981	0.999
	Postimplementation	0.989	0.980	0.999
	Postimplementation vs Preimplementation	0.988	0.975	1.002	0.086
	Estimated intervention effect	1.045	0.868	1.259	0.640
CRP						0.154
	Preimplementation	1.014	1.002	1.026
	During-implementation	1.007	0.997	1.018
	Postimplementation	1.000	0.994	1.006
	Postimplementation vs Preimplementation	0.987	0.974	1.000	0.044*
	Estimated intervention effect	1.099	0.893	1.353	0.374

For each test, the ‘post vs pre’ line reflects the slope change, and the ‘estimated intervention effect’ line reflects the step change.
*Significant at <0.05.
CRP, C reactive protein; FBC, full blood count; TSH, thyroid-stimulating hormone; UEC, urea, electrolytes and creatinine.