Table 2

Clinical features of the five cases with NTRK gene alterations in colorectal adenocarcinoma

Case IDSexSize (cm)DifferentiationTNMNTRK gene alterationMismatch repair protein expression
1M6.0LowT3, N0, M0TPM3-NTRK1 fusionMLH1/PMS2 deficiency
2M8.0LowT3, N0, M0TPR-NTRK1 fusionMLH1/PMS2 deficiency
3F6.0LowT3, N1, M1TPM3-NTRK1 fusionMLH1/PMS2 deficiency
4M5.0HighT3, N0, M0NTRK3-hoxc13 fusionPMS2 deficiency
5F2.6HighT3, N0, M05’-telomere-NTRK1 fusionMLH1/PMS2 deficiency
  • F, female; M, male.