Variables | Overall (n=402) | PD-L1 with CPS ≥20 (n=168) | PD-L1 with CPS <20 (n=234) | OR (95% CI)* | P value* |
Sex | |||||
Male | 346 | 129 (37.3%) | 217 (62.7%) | 3.86 (2.097 to 7.101) | <0.0001 |
Female | 56 | 39 (69.6%) | 17 (30.4%) | ||
Smoking habit | |||||
Current smoker | 94 | 33 (35.1%) | 61 (64.9%) | 1 | |
Former smoker | 125 | 43 (34.4%) | 82 (65.6%) | 0.97 (0.553 to 1.700) | 0.9135 |
Non-smoker | 177 | 90 (50.8%) | 87 (49.2%) | 1.91 (1.141 to 3.203) | 0.0138 |
Primary tumour site | |||||
Oral cavity | 189 | 98 (51.9%) | 91 (48.1%) | 1 | |
Oropharynx | 22 | 7 (31.8%) | 15 (68.2%) | 0.43 (0.169 to 1.111) | 0.0817 |
Hypopharynx | 70 | 13 (18.6%) | 57 (81.4%) | 0.21 (0.109 to 0.412) | <0.0001 |
Larynx | 99 | 38 (38.4%) | 61 (61.6%) | 0.58 (0.352 to 0.949) | 0.0304 |
Others | 22 | 12 (54.5%) | 10 (45.5%) | 1.11 (0.459 to 2.704) | 0.8109 |
Footnote: The row percentage is calculated.
*OR, 95% CI or p value are calculated by univariate logistic regression. P values are rounded to four decimal places. OR values are rounded to two decimal places. The lower and upper bounds of CI are rounded to three decimal places.
CPS, combined positive score; PD-L1, programmed death-ligand 1; R/M HNSCC, recurrent or metastatic head and neck squamous cell carcinoma.