Regular ArticleHigh-Resolution Liquid Chromatography of Oligonucleotides on Nonporous Alkylated Styrene-Divinylbenzene Copolymers
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Separation of therapeutic oligonucleotides using ion-pair reversed-phase chromatography based on fundamental separation science
2023, Journal of Chromatography OpenSalt gradient and ion-pair mediated anion exchange of intact messenger ribonucleic acids
2022, Journal of Chromatography OpenThe impact of low adsorption surfaces for the analysis of DNA and RNA oligonucleotides
2022, Journal of Chromatography AEffect of ion-pairing reagent hydrophobicity on liquid chromatography and mass spectrometry analysis of oligonucleotides
2022, Journal of Chromatography AHPLC of carbohydrates with cation-exchange silica and resin-based stationary phases
2021, Carbohydrate Analysis by Modern Liquid Phase Separation TechniquesMultiple heart-cutting mixed-mode chromatography-reversed-phase 2D-liquid chromatography method for separation and mass spectrometric characterization of synthetic oligonucleotides
2020, Journal of Chromatography ACitation Excerpt :For both, ion-pair reversed-phase liquid chromatography (IP-RPLC) with triethylammonium acetate as ion-pairing agent is the state-of-the-art technology because oligonucleotides are only poorly retained by common RPLC [6,7]. The type of ion-pairing agent utilized may significantly affect selectivities and is a prime variable for optimization; triethylamine (TEA), propylamine, tripropylamine, dibutylamine and hexylamine are some preferred choices [8–13]. The effect of stationary phases in IP-RPLC has been investigated as well [14–16].
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