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ICSAT Overexpression Is Not Sufficient to Cause Adult T-Cell Leukemia or Multiple Myeloma

https://doi.org/10.1006/bbrc.1999.0911Get rights and content

Abstract

ICSAT (Interferon Consensus Sequence binding protein for Activated T cells) is a lymphocyte-specific member of the interferon regulatory factor (IRF) family of transcription factors, originally identified through Southwestern screening of the ATL(Adult T-cell leukemia)-16T expression library. In this study, we created transgenic mice overexpressing ICSAT in lymphocytes. Although spontaneous tumorigenesis was not observed, IL-2 production with Concanavalin A stimulation was significantly increased in transgenic mice overexpressing ICSAT. ICSAT overexpression in lymphocytes seems insufficient for the leukemogenesis of ATL or multiple myeloma (MM), however, it may regulate T cell activation and its overexpression may lead to leukemogenesis via controlling IL-2 production.

References (12)

  • G. Kollias et al.

    Cell

    (1986)
  • H. Honda et al.

    Blood

    (1995)
  • T. Matsuyama et al.

    Nucleic Acids Res.

    (1995)
  • C.F. Eisenbeis et al.

    Genes. Dev.

    (1995)
  • T. Yamagata et al.

    Mol. Cell. Biol.

    (1996)
There are more references available in the full text version of this article.

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