Full PapersN-Cadherin Involvement in Cardiac Myocyte Interaction and Myofibrillogenesis
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N-Cadherin is a prospective cell surface marker of human mesenchymal stem cells that have high ability for cardiomyocyte differentiation
2013, Biochemical and Biophysical Research CommunicationsCitation Excerpt :N-Cadherin is localized in the cell–cell contacts of cardiomyocytes and plays essential roles for formation of the cardiac intercalated disk structure that electromechanically couples adjacent cardiac myocytes. Addition of antibodies against N-cadherin to the cultured cardiomyocytes [20], mesodermal explants [21] or injected into embryos [22] caused a reduction in the number of myofibrils and destroy stress fibers [23]. In primary cardiomyocytes dissociated from adult rat heart, N-cadherin diffusely distributed around the cell periphery begins to co-localize with desmocollin, plakoglobin, and plakophilin-2 at the cell contact sites.
N-Cadherin-mediated adhesion and signaling from development to disease: Lessons from mice
2013, Progress in Molecular Biology and Translational ScienceCitation Excerpt :As earlier studies demonstrated the importance of N-cadherin for myofibril formation and maintenance, this result was not expected. These former studies employed function-blocking antibodies33,34 or dominant-negative cadherin molecules35 to perturb N-cadherin function in cultured cardiomyocytes. The discrepancy in these results may be explained by the different experimental approaches.
Neuronal cadherin (NCAD) increases sensory neurite formation and outgrowth on astrocytes
2012, Neuroscience LettersCitation Excerpt :Function blocking antibodies, however, may have unintended effects, including binding to other molecules and/or steric hindrance. Genetic deletion of the corresponding molecule transcends these limitations, and has both confirmed and repudiated prior blocking antibody studies that implicated NCAD in various cellular interactions [8,32,51]. Because mice lacking NCAD have many developmental defects and die embryonically [45], we have developed an in vitro neurite outgrowth assay after deleting NCAD from astrocytes cultured from Ncadflox/flox mice with an adeno-associated virus (AAV) that expresses Cre recombinase.
Apoptosis-related factors p53, bcl-2 and the defects of force transmission in dilated cardiomyopathy
2010, Pathology Research and PracticeDysregulation of cadherins in the intercalated disc of the spontaneously hypertensive stroke-prone rat
2010, Journal of Molecular and Cellular CardiologyCitation Excerpt :The reorganisation of homophilic cell–cell adhesion is mainly regulated by the cadherin/catenin system, which is differentially modulated to sustain cell structural rather than signalling needs. N-cadherin, which is normally expressed in the adult heart is required for maintenance of the structural integrity and myofibril continuity across the plasma membrane [27,28]. In the SHRSP model, levels of N-cadherin appeared to be relatively unaltered compared to controls.
Protein kinase C-Fyn kinase cascade mediates the oleic acid-induced disassembly of neonatal rat cardiomyocyte adherens junctions
2009, International Journal of Biochemistry and Cell Biology