Elsevier

Genomics

Volume 52, Issue 2, 1 September 1998, Pages 233-235
Genomics

Short Communication
Asthma and Bronchial Hyperresponsiveness Linked to the XY Long Arm Pseudoautosomal Region

https://doi.org/10.1006/geno.1998.5445Get rights and content
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Abstract

We examined the long arm XY pseudoautosomal region for linkage to asthma, serum IgE, and bronchial hyperresponsiveness. In 57 Caucasian families multipoint nonparametric analyses provide evidence for linkage between DXYS154 and bronchial hyperresponsiveness (P= 0.000057) or asthma (P= 0.00065). This genomic region is approximately 320 kb in size and contains the interleukin-9 receptor gene. These results suggest that a gene controlling asthma and bronchial hyperresponsiveness maybe located in this region and that the interleukin-9 receptor is a potential candidate.

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To whom correspondence should be addressed at the Magainin Institute of Molecular Medicine, Magainin Pharmaceuticals, 5110 Campus Drive, Plymouth Meeting, Pennsylvania 19462. Telephone: (610) 941-5248. Fax: (610) 941-5399. E-mail:[email protected].