Regular ArticleThe Prognostic Significance of Lymphovascular Space Invasion in Endometrial Cancer When Conventional Hemotoxylin and Eosin Staining Is Compared to Immunohistochemical Staining
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Lymphovascular invasion as a criterion for adjuvant chemotherapy for FIGO stage I-IIa clear cell carcinoma, mucinous, low grade serous and low grade endometrioid ovarian cancer
2021, Journal of Gynecology Obstetrics and Human ReproductionExtent of lymphovascular space invasion may predict lymph node metastasis in uterine serous carcinoma
2017, Gynecologic OncologyCitation Excerpt :Histopathologic factors obtained from the hysterectomy specimen provide critical information that allows clinicians to risk stratify and determine appropriate adjuvant treatment for patients. One such factor is lymphovascular space invasion (LVSI), which has been shown to be associated with increased risk of nodal metastases and worsened survival outcomes in women with endometrial cancer [7–11]. However for women with USC, evidence suggests that traditional clinicopathologic risk factors, such as depth of myometrial invasion [12–14], may be much less helpful for risk stratification, and that alternative prognostic markers based on novel techniques are needed to better identify patients who could benefit from adjuvant therapy [15].
Survival outcome of stage I ovarian clear cell carcinoma with lympho-vascular space invasion
2015, Gynecologic OncologyCitation Excerpt :The key finding of this study is that LVSI is a strong predictor of survival outcomes in patients with stage I OCCC. The prognostic significance of LVSI has been reported in other types of gynecologic malignancies such as cervical [13,14], endometrial [15,16], and vulvar cancers [17]. The remarkable prognostic significance of LVSI in OCCC appears to be of larger magnitude than that seen in other gynecologic malignancies; HRs for LVSI on survival outcomes for the aforementioned gynecologic malignancies ranged from 1.98 to 2.84, which are smaller than those of OCCC (adjusted-HRs for DFS 4.35 and for OS 4.73, Table 3) [9,13–17].
Subendometrial enhancement and peritumoral enhancement for assessing endometrial cancer on dynamic contrast enhanced MR imaging
2015, European Journal of RadiologyCitation Excerpt :Additionally, the presence of myometrial invasion is still important for the fertility-sparing progestogen therapy [4]. Lymphovascular space involvement (LVSI) is an important prognostic factor for disease relapse and poor survival [5–8], as is pelvic lymph node metastases in patients with endometrial cancer [7,9,10]. To our knowledge, there is no report describing the relationship between LVSI and MR imaging findings.
Association between tumor diameter and lymphovascular space invasion among women with early-stage endometrial cancer
2013, International Journal of Gynecology and ObstetricsCitation Excerpt :Unfortunately, there is a lot of heterogeneity in the diagnosis of LVSI by permanent section, let alone frozen section, analysis. This is reflected by the varying percentages of LVSI reported for different series of patients with EC, and by the fact that a study comparing LVSI diagnosed by frozen section with that diagnosed by permanent section shows a relatively low agreement (68.3%) [10–13]. Given the present results and the difficulties in diagnosing LVSI intraoperatively, it does not seem unreasonable to incorporate tumor diameter as a surrogate of LVSI at the time of surgery in order to triage patients for a full surgical staging.
Retrospective analysis of prognostic variables and clinical outcomes in surgically staged intermediate risk endometrial carcinoma
2013, European Journal of Obstetrics and Gynecology and Reproductive Biology