Regular ArticleThe Significance of Human Papillomavirus Viral Load in Prediction of Histologic Severity and Size of Squamous Intraepithelial Lesions of Uterine Cervix☆
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Cited by (98)
Development and interlaboratory agreement of real-time PCR for HPV16 quantification in liquid-based cervical samples
2018, Papillomavirus ResearchHuman papillomavirus type 16 viral load in relation to HIV infection, cervical neoplasia and cancer in Senegal
2014, Cancer EpidemiologyCitation Excerpt :Few other studies to date have been able to quantitatively examine the relationship between HPV-16 viral load and cervical disease outcomes including invasive cancer, especially among both HIV-infected and HIV-uninfected individuals [17,21]. Several other studies in addition to ours have found an association between increasing HPV-16 viral load and increasing severity of cervical disease [5,13,38–40]. However, even as HPV-16 viral loads were observed to increase with cervical lesion severity in our study, there was a substantial overlap in the range of viral loads between categories of cervical abnormalities, even among those with normal cytological diagnoses.
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Supported by National Health Research Institute (Taiwan, ROC) Grant DOH 88 HR-805 and National Science Council (Taiwan, ROC) Grants NSC89-2314-B-016-044 and NSC 88-2314-B-016-112.
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To whom reprint requests should be addressed at Department of Obstetrics and Gynecology, Tri-Service General Hospital, 325, Section 2, Chengon Road, Taipei 114, Taiwan, ROC. Fax: +866-2-87927207.