Elsevier

Gynecologic Oncology

Volume 83, Issue 2, November 2001, Pages 418-421
Gynecologic Oncology

Case Report
An α-Fetoprotein-Producing Hepatoid Adenocarcinoma of the Endometrium

https://doi.org/10.1006/gyno.2001.6383Get rights and content

Abstract

Background. Hepatoid adenocarcinomas are tumors that arise outside the liver but resemble hepatic tissue and produce α-fetoprotein. These neoplasms have been described in many locations, including the lung, gastrointestinal tract, and urogenital tract, and have been associated with a poor prognosis. Two previously reported cases of hepatoid adenocarcinoma of the endometrium described aggressive tumors that were unresponsive to multiple forms of therapy.

Case. We report a case of an α-fetoprotein-producing hepatoid adenocarcinoma of the endometrium that was successfully treated with surgery and adjuvant chemotherapy.

Conclusion. Eight years after therapy, the patient is alive with no evidence of disease, suggesting that cytoxan, adriamycin, and cis-platinum are active agents in this unusual entity.

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