Regular Article
Expression Patterns ofJagged, Delta1, Notch1, Notch2,andNotch3Genes Identify Ligand–Receptor Pairs That May Function in Neural Development

https://doi.org/10.1006/mcne.1996.0040Get rights and content

Abstract

Notchgenes encode receptors for a signaling pathway that regulates neurogenesis. TheDSL(Delta/Serrate/lag-2) genes encode ligands that bind and activate Notch.In situhybridization was used to determine the spatiotemporal expression of Notch1, Notch2, and Notch3, and the DSL ligands, Jagged and Delta1, in an effort to identify potential ligand–receptor pairs that function during development of the rat nervous system. Here we describe both distinct and overlapping expression patterns for these genes in neural progenitors that form both the central and the peripheral nervous systems. The punctate expression patterns we detected for Jagged and Delta1 are consistent with their role in mediating lateral inhibition, a process proposed to regulate neural determination. Furthermore, within the ventricular zone of the neural tube and retina, Jagged and Delta1 were expressed in complementary regions, suggesting that different DSL–Notch combinations may direct the development of distinct neural subtypes.

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