Regular Article
The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues

https://doi.org/10.1006/scbi.1998.0119Get rights and content

Abstract

The human CEA family has been fully characterized. It comprizes 29 genes of which 18 are expressed; 7 belonging to the CEA subgroup and 11 to the pregnancy specific glycoprotein subgroup. CEA is an important tumor marker for colorectal and some other carcinomas. The CEA subgroup members are cell membrane associated and show a complex expression pattern in normal and cancerous tissues with notably CEA showing a selective epithelial expression. Several CEA subgroup members possess cell adhesion properties and the primordial member, biliary glycoprotein, seems to function in signal transduction or regulation of signal transduction possibly in association with other CEA sub-family members. A modified ITAM/ITIM motif is identified in the cytoplasmatic domain of BGP. A role of CEA in innate immunity is envisioned.

References (103)

  • BF Brandriff et al.

    Order and genomic distances among members of the carcinoembryonic antigen (CEA) gene family determined by fluorescence in situ hybridization

    Genomics

    (1992)
  • GQ Zhou et al.

    Highly specific monoclonal antibody demonstrates that pregnancy-specific glycoprotein (PSG) is limited to syncytiotrophoblast in human early and term placenta

    Placenta

    (1997)
  • S Teglund et al.

    Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants

    Biochem Biophys Res Commun

    (1995)
  • S Benchimol et al.

    Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule

    Cell

    (1989)
  • W Hauck et al.

    Transcriptional regulation of the carcinoembryonic antigen gene

    Identification of regulatory elements and multiple nuclear factors. J Biol Chem

    (1995)
  • D Metze et al.

    Glycoproteins of the carcinoembryonic antigen (CEA) family are expressed in sweat and sebaceous glands of human fetal and adult skin

    J Invest Dermatol

    (1996)
  • S Oikawa et al.

    Homotypic and heterotypic Ca2+-independent cell adhesion activities of biliary glycoprotein, a member of carcinoembryonic antigen family, expressed on CHO cell surface

    Biochem Biophys Res Commun

    (1992)
  • CJ Sippel et al.

    Site-directed mutagenesis wit hin an ectoplasmic ATPase consensus sequence abrogates the cell aggregating properties of the liver canlicular bile acid transporter/ecto-ATPase/cell CAM 105 and carcinoembryonic antigen

    J Biol Chem

    (1996)
  • H Olsson et al.

    Cell adhesion activity of the short cytoplasmic domain isoform of C-CAM (C-CAM2) in CHO cells

    FEBS Lett

    (1995)
  • SL Sauter et al.

    Identification of the specific oligosaccharide sites recognized by type 1 fimbriae from Escherichia coli on nonspecific cross-reacting antigen, a CD66 cluster granulocyte glycoprotein

    J Biol Chem

    (1993)
  • HG Leusch et al.

    Escherchia coli of human origin binds to carcinoembryonic antigen (CEA) and non-specific cross-reacting antigen (NCA)

    FEBS Lett

    (1990)
  • J Thompson et al.

    Carcinoembryonic antigen gene family: molecular biology and clinical perspectives

    J Clin Labor Anal

    (1991)
  • S Hammarström et al.

    The carcinoembryonic antigen family

  • S Hammarström et al.

    The nature and expression of the human CEA family

  • P Gold et al.

    Specific carcinoembryonic antigens of the human digestive system

    J Exp Med

    (1965)
  • DMP Thomson et al.

    The radioimmunoassa y of circulating carcinoembryonic antigen of the human digestive tract

    Proc Natl Acad Sci USA

    (1966)
  • RA Graham et al.

    Postsurgical surveil lance of colon cancer

    Ann Surg

    (1998)
  • J Krupey et al.

    The preparation of puri fied carcinoembryonic antigen of the human digestive system from large quantities of tumor tissue

    Immunochemistry

    (1966)
  • S Hammarström et al.

    Nature of the tumor-associated determinants of carcinoembryonic antigen

    Proc Natl Acad Sci USA

    (1975)
  • Hammarström, S, Engvall, E, Sundblad, G, 1976, Carcinoembryonic antigen (CEA): purification, structure and antigenic...
  • JE Coligan et al.

    Isolation and characterization of carcinoembryonic antigen

    Immunochemistry

    (1972)
  • JH Westwood et al.

    Studie s on the structure of the carcinoembryonic antigen. I. Some deductions on the basis of chemical degradations

    Immunochemistry

    (1974)
  • S von Kleist et al.

    Identification of an antige n from normal human tissue that crossreacts with the carcinoembryonic antigen

    Proc Natl Acad Sci USA

    (1972)
  • T Svenberg

    Carcinoembryonic antigen-like substances of human bile

    Isolation and partial characterization. Int J Cancer

    (1976)
  • TM Behr et al.

    Factors influencing the pharmacokinetics, dosimetry and diagnostic accuracy of radioimmunodetection and radioimmunotheraphy of carcinoembryonic antigen-expressing tumors

    Cancer Res

    (1996)
  • TM Behr et al.

    Phase I/II clinical radioimmunotheraphy with an iodine-131-labeled anti-carcinoembryonic antigen murine monoclonal antibody IgG

    J Nucl Med

    (1997)
  • CA Vogel et al.

    Direct comparison of radioiodinated intact chimeric anti CEA Mab with its F (ab′)2 fragment in nude mice bearing different human cancer xenografts

    Br J Cancer

    (1993)
  • M Ychou et al.

    Phase I/II radio-immunotherapy Iodine-131-labeled anti-CEA monoclonal antibody F6 F(ab′)2 in patients with non-resectable liver metastases from colorectal cancer

    Int J Cancer

    (1998)
  • C Delgado et al.

    Enhanced tumour specificity of an anti-carcinoembryonic antigen Fab′ fragment by poly(ethylene glycol) (PEG) modification

    Br J Cancer

    (1996)
  • N Beauchemin et al.

    Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen

    Mol Cell Biol

    (1987)
  • Y Hinoda et al.

    Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen

    Proc Natl Acad Sci USA

    (1988)
  • TR Barnett et al.

    Carcinoembryonic antigens: Alternative splicing accounts for the multiple mRNAs that code for novel members of the carcinoembryonic antigen family

    J Cell Biol

    (1989)
  • M Kuroki et al.

    Molecular cloning of nonspecific cross-reacting antigens in human granulocytes

    J Biol Chem

    (1991)
  • B Berling et al.

    Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow

    Cancer Res

    (1990)
  • YS Tatarinov et al.

    Immunological identification of a new beta 1-globulin in the blood of pregnant women

    Bull Exp Biol Med

    (1970)
  • W Zimmermann et al.

    Chromosomal localization of the carcinoembryonic antigen gene family and differential expression in various tumors

    Cancer Res

    (1988)
  • RJ Paxton et al.

    Sequence analysis of carcinoembryonic antigen: identification of glycosylation sites and homology with the immunoglobulin supergene family

    Proc Natl Acad Sci USA

    (1987)
  • AF Williams et al.

    The immunoglobulin superfamily—domain s for cell surface recognition

    Annul Rev Immunol

    (1988)
  • B Öbrink

    CEA adhesion molecules: multifunctional proteins with signal-regulatory properties

    Curr Opin Cell Biol

    (1997)
  • G Nagel et al.

    Genomic organization, splice variants and expression of CGM1, a CD66-related member of the carcinoembryonic antigen gene family

    Eur J Biochem

    (1993)
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